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Polymer vesica with antibacterial nano silver deposited on surface and preparation method thereof

A technology of surface deposition and nano-silver, which is applied in the direction of medical preparations and pharmaceutical formulas with non-active ingredients, can solve the problems of complex preparation methods, inconvenient use, complex nano-silver reagents and coating components, etc., and achieve simple preparation methods, Wide range of effects

Inactive Publication Date: 2012-05-02
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although the nano-silver prepared above has certain antibacterial and antibacterial effects, its preparation method is relatively complicated, and the prepared nano-silver reagent and coating film components are complex, inconvenient to use, and the application area is also relatively narrow.
[0008] To sum up, the research on polymer vesicles with nano-silver deposited on the surface is of great significance, especially in the antibacterial and antibacterial aspects of nano-silver and the drug carrier of vesicles, and there is no related patent invention in China.

Method used

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  • Polymer vesica with antibacterial nano silver deposited on surface and preparation method thereof
  • Polymer vesica with antibacterial nano silver deposited on surface and preparation method thereof
  • Polymer vesica with antibacterial nano silver deposited on surface and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Macromolecular initiator PEO 43 -Synthesis of Br

[0035] Azeotropically distill 10g of flake PEO and 250mL of toluene to remove excess water, lower the temperature of the system to room temperature, change to an ice-water bath, add 2mL of triethylamine, 20mL of toluene solution of 1.9mL of 2-bromoisobutyryl bromide, The reaction was carried out for 40h, filtered, extracted, and the organic phase was collected, dried, filtered, precipitated, suction filtered, and vacuum-dried to obtain a white powdery macromolecular initiator PEO 43 -Br.

[0036] (2) ATRP synthetic polymer

[0037] 0.5g of macroinitiator PEO 43 -Br, 0.035g of catalyst cuprous bromide (CuBr), 0.040g of ligand PMDETA, 1.16g of monomer dimethylaminoethyl methacrylate (DMA), 3.16g of tert-butyl acrylate ( t BA) and 2mL of methanol solvent were added to a 50mL round-bottomed flask, and atom transfer radical polymerization (ATRP) was carried out under the protection of nitrogen or argon in anhydrous a...

Embodiment 2

[0046] (1) Macromolecular initiator PEO 43 -Synthesis of Br

[0047] Azeotropically distill 10g of flake PEO and 250mL of toluene to remove excess water, lower the temperature of the system to room temperature, change to an ice-water bath, add 2mL of triethylamine, 20mL of toluene solution of 1.9mL of 2-bromoisobutyryl bromide, The reaction was carried out for 40h, filtered, extracted, and the organic phase was collected, dried, filtered, precipitated, suction filtered, and vacuum-dried to obtain a white powdery macromolecular initiator PEO 43 -Br.

[0048] (2) ATRP synthetic polymer

[0049] 0.5g of macroinitiator PEO 43 -Br, 0.035g of catalyst cuprous bromide (CuBr), 0.040g of ligand PMDETA, 1.16g of monomer dimethylaminoethyl methacrylate (DMA), 2.06g of tert-butyl acrylate ( t BA) and 2mL of methanol solvent were added to a 50mL round-bottomed flask, and atom transfer radical polymerization (ATRP) was carried out under the protection of nitrogen or argon in anhydrous a...

Embodiment 3

[0055] (1) Macromolecular initiator PEO 45 -Synthesis of Br

[0056] Azeotropically distill 10g of flake PEO and 250mL of toluene to remove excess water, lower the temperature of the system to room temperature, change to an ice-water bath, add 2mL of triethylamine, 1.0mL of 2-bromoisobutyryl bromide in 20mL of toluene, The reaction was carried out for 40h, filtered, extracted, and the organic phase was collected, dried, filtered, precipitated, suction filtered, and vacuum-dried to obtain a white powdery macromolecular initiator PEO 43 -Br.

[0057] (2) ATRP synthetic polymer

[0058] 0.5g of macroinitiator PEO 43 -Br, 0.035g of catalyst cuprous bromide (CuBr), 0.040g of ligand PMDETA, 0.86g of monomer dimethylaminoethyl methacrylate (DMA), 3.56g of tert-butyl acrylate ( t BA) and 2mL of methanol solvent were added to a 50mL round-bottomed flask, and atom transfer radical polymerization (ATRP) was carried out under the protection of nitrogen or argon in anhydrous and oxygen...

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Abstract

The invention belongs to the field of nano biological medical materials and particularly relates to polymer vesica with the surface deposited with antibacterial nano silver and a preparation method thereof. Amphipathic block polymers are self-assembled by a cosolvent method to form the vesica, and then the nano silver is generated in situ on the surface of the vesica. The polymer vesica has biocompatibility and has certain temperature and pH sensitivity; a cavity structure of the vesica can wrap various medicines; and simultaneously, due to the existence of the nano silver, the vesica also has the curative effects of sterilization and bactriostasis.

Description

technical field [0001] The invention belongs to the field of macromolecular nano biomedical materials, in particular to a polymer vesicle with antibacterial nano silver deposited on the surface and a preparation method thereof. Background technique [0002] In recent years, the preparation of polymer vesicles by self-assembly technology has attracted more and more attention from scientists from all over the world, because the polymer molecules that make up the vesicles will have corresponding shapes, The change in structure or composition, therefore, endows polymersomes with many excellent properties. Based on this, polymersomes have a wide range of application prospects in many fields, such as drug loading, gene carriers, biomineralization Templates, microreactors, biological scaffolds, etc. [0003] Amphiphilic block polymers can self-assemble in water to form vesicles with bilayer membranes. Compared with liposome vesicles, polymer vesicles have greatly improved mechanic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L53/00C08K3/08C08F293/00C08F220/18C08F220/34C08J3/07A61K47/32
Inventor 杜建忠路航
Owner TONGJI UNIV
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