High-purity torasemide compound

A technology of torasemide and compounds, applied in the field of medicine, to achieve the effects of high yield, improved therapeutic effect, and low content of related substances

Active Publication Date: 2012-05-02
TIANJIN HANKANG PHARMA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The yield is usually 50-60%, and the purity is below 99%. There is currently no good way

Method used

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  • High-purity torasemide compound
  • High-purity torasemide compound
  • High-purity torasemide compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Take 5g of torasemide, add 115ml of isopropanol and 4ml of water, and heat to dissolve it. After all the solids are dissolved, continue heating, distill 36ml of liquid under normal pressure, cool to 0°C, stir, crystallize for 2 hours, filter after crystallization, and vacuum dry at 80°C for 4 hours to obtain 4.57g of pure crystals. The purity detected by HPLC was 99.9%.

Embodiment 2

[0060] Take torasemide 8, add 124 isopropanol and 6.4, and heat to dissolve it. After the solid is completely dissolved, add 54ml of isopropanol, cool to 0°C, stir, crystallize for 4 hours, filter after crystallization, and vacuum dry at 80°C for 4 hours to obtain pure crystalline product, 7.68g, which was detected by HPLC 99.9%.

Embodiment 3

[0062] Take 5g of torasemide, add 200ml of ethanol, heat to dissolve the solid, cool, stir at 10°C, crystallize for 2 hours, filter, and vacuum dry at 80°C for 4 hours to obtain 4.59g of pure crystalline product, which is detected by HPLC 99.9%.

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PUM

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a torasemide compound. The torasemide compound obtained in the invention has the advantages of small relevant substances, high purity, good stability and unobvious moisture absorption and weight increment even under the condition of high humidity.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a torasemide compound and a preparation method thereof. Background technique [0002] Hypertension is one of the clinical frequently-occurring diseases, often accompanied by a variety of cardiovascular risk factors. my country has conducted three large-scale sampling surveys of hypertensive populations. The most recent survey was in 2002. The prevalence of hypertension among residents over the age of 18 in my country was 18.8%, and it showed an obvious upward trend. It is estimated that the number of hypertensive patients in my country exceeds 160 million. [0003] Diuretics reduce the amount of sodium and water circulating in the body through natriuresis and diuresis, reducing blood volume and lowering blood pressure. According to their different action characteristics, they can be divided into thiazides, loop diuretics and potassium-sparing diuretics. Diuretics h...

Claims

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Application Information

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IPC IPC(8): C07D213/74
Inventor 严洁黄欣
Owner TIANJIN HANKANG PHARMA BIOTECH
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