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Paclitaxel compound preparation and preparation method thereof

A compound preparation, the technology of paclitaxel, applied in the field of medicine, can solve the problems of low blood drug concentration, difficult to achieve anti-cancer efficacy, difficult to absorb, etc., and achieve the effects of good curative effect, low oral bioavailability and poor water solubility

Active Publication Date: 2013-08-21
FIELD OPERATION BLOOD TRANSFUSION INST OF PLA SCI ACAD OF MILITARY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to solve the problems that the existing paclitaxel is difficult to absorb when taken orally, the blood concentration is low, and it is difficult to achieve the anticancer effect by oral administration. Paclitaxel compound preparation with cancer effect

Method used

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  • Paclitaxel compound preparation and preparation method thereof
  • Paclitaxel compound preparation and preparation method thereof
  • Paclitaxel compound preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0029] Embodiment 1-4, the preparation of paclitaxel compound preparation

[0030] The formulations of paclitaxel compound preparations in Examples 1-4 of the present invention are shown in Table 1.

[0031] The formula of table 1 embodiment 1-4 paclitaxel compound preparation (preparation by weight)

[0032] Numbering

paclitaxel

20(s)-Ginsenoside Rg3

Example 1

1 part, 98% pure

0.1 parts, purity 97%

Example 2

1 part, 98% pure

0.25 parts, purity 97%

Example 3

1 part, 98% pure

0.5 parts, purity 97%

Example 4

1 part, 98% pure

0.25 parts, 70% purity

[0033] The unit of parts by weight is kilogram or gram, and the base value of 1 part can be designed according to the size of the required amount.

[0034] Conventional preparation methods can be used to prepare the paclitaxel compound preparation of the present invention. Paclitaxel and 20(s)-ginsenoside Rg3 can be used as compound medicinal active...

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Abstract

The invention discloses a paclitaxel compound preparation and a preparation method thereof. The preparation method of the paclitaxel compound preparation comprises that: paclitaxel and 20(s)-ginsenoside Rg3 are mixed in a weight ratio of 1: (0.1-0.5). Compared with the existing paclitaxel medicines, the paclitaxel compound preparation has the following advantages: 1) the curative effect is good, the toxicity is low, and the oral administration safety is higher; 2) the preparation is convenient to take; and 3) the preparation process is simple, has low cost and is suitable for large-scale industrial production. The paclitaxel compound preparation and preparation method can play important roles in the preparation and clinical application fields of the paclitaxel medicine and have wide application prospects.

Description

technical field [0001] The invention belongs to the field of medicines, in particular to a paclitaxel compound preparation and a preparation method thereof. Background technique [0002] Paclitaxel, a compound proposed from the bark of Taxus brevifolia, is a specific stabilizer of microtubules, which can promote the assembly of microtubules and maintain the stability of microtubules. Paclitaxel inhibits depolymerization by promoting tubulin polymerization, keeps tubulin stable, and inhibits cell mitosis. In vitro experiments have shown that paclitaxel has a significant radiosensitizing effect, which may cause cells to stop in the G2 and M phases that are sensitive to radiotherapy. Through II-III clinical research, paclitaxel is mainly applicable to ovarian cancer and breast cancer, and has certain curative effect on lung cancer, colorectal cancer, melanoma, head and neck cancer, lymphoma and brain tumor. However, paclitaxel is difficult to absorb when taken orally, and the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61K31/337A61K9/48A61P35/00
Inventor 窦桂芳杨雷琼王彬孟志云朱晓霞甘慧吴卓娜顾若兰
Owner FIELD OPERATION BLOOD TRANSFUSION INST OF PLA SCI ACAD OF MILITARY
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