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Mesoporous magnetic ferriferrous oxide, its preparation method and application

A ferric tetroxide, magnetic technology, applied in the direction of iron oxide/iron hydroxide, ferrous oxide, inorganic inactive ingredients, etc.

Inactive Publication Date: 2012-04-18
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Deng et al. used ethylene glycol as a solvent to hydrolyze FeCl3·6H2O in the presence of sodium acetate to obtain Fe3O4 particles with a particle size of 200-800 nm. The particle size is mainly affected by the reaction time (Deng H, Li X L, Peng Q , et al. Angew. Chem. Inter. Ed., 2005, 44: 2782-2785.) However, the currently reported method to prepare magnetic Fe3O4 nanocrystals and Most of its nanocomposites are non-porous magnetic materials, and the magnetic Fe3O4 nanocrystals have long-term stability problems

Method used

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  • Mesoporous magnetic ferriferrous oxide, its preparation method and application
  • Mesoporous magnetic ferriferrous oxide, its preparation method and application
  • Mesoporous magnetic ferriferrous oxide, its preparation method and application

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Embodiment 1

[0015] Example 1 (example of optimal reaction conditions):

[0016] Weigh 10.032g FeCl 3 ·6H 2 O (0.037mol) and 2ml ethylene glycol (molar ratio 1:1), stir to form a clear yellow solution, then add 3.0017g NaAc, 7.6ml ethylenetriamine (in which FeCl 3 ·6H 2 The molar ratio of O:NaAc:amine is 1:1:2), in the reaction kettle, 120 ℃, react for 6 hours, naturally cooled to room temperature, centrifuged, washed with water 4 times, and dried to obtain 8.42 g of black solid particles, the yield, 84%, particle size 15-20 nm. Surface area is 21.04 m 2 / g, the pore size is 9.50 nm. IR cm -1 : 582: vibration absorption peak of Fe-O bond, 1571: N-H in-plane deformation vibration, 3404: N-H asymmetric stretching vibration.

Embodiment 2

[0018] Preparation of mesoporous magnetic ferric oxide: Weigh 10.032g FeCl 3 ·6H 2 O (0.037mol) and 2ml ethylene glycol (molar ratio 1:1), stir to form a clear yellow solution, then add 3.0017g NaAc, 3.8ml ethylenetriamine (in which FeCl 3 ·6H 2 The molar ratio of O:NaAc:amine is 1:1:1), in the reaction kettle, 180 ℃, react for 4 hours, naturally cooled to room temperature, centrifuged, washed 4 times with water, and dried to obtain 6.21 g of black solid particles with a yield of 62 %.

Embodiment 3

[0020] Preparation of mesoporous magnetic ferric oxide: Weigh 10.032g FeCl 3 ·6H 2 O (0.037mol) and 2ml ethylene glycol (molar ratio 1:1), stir to form a clear yellow solution, then add 3.0017g NaAc, 22.4ml ethylenetriamine ((FeCl 3 ·6H 2 O:NaAc:Amine molar ratio is 1:1:6), in the reaction kettle, 110 ℃, react for 6 hours, naturally cooled to room temperature, centrifuged, washed 4 times with water, dried to obtain black solid particles 5.67g, yield 56 %.

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Abstract

The invention discloses mesoporous magnetic ferriferrous oxide, its preparation method and application, relating to the technical field of targeting carriers and preparation technology thereof. A mesoporous magnetic ferriferrous oxide crystal has the nanoparticle size of 10-50 nm, a pore size of 6-10 nm, and a surface area of 21-90 m<2> / g. The preparation method comprises the following steps: weighing FeCl3.6H2O and glycol, stirring to form a clear yellow solution, then adding NaAc, diethylenetriamine or ethene diamine in a reaction vessel, carrying out reaction for 4-10 h at the temperature of 90-180 DEG C, naturally cooling to room temperature, carrying out centrifugation, washing 4 times with water, and drying to obtain black solid particles with the particle size of 10-40 nm and the yield of 84 %. The mesoporous magnetic ferriferrous oxide can be used for a carrier for a targeting antitumor drug, has the advantages of good dispersibility, good stability, and controllable size, and is benefit for industrial production.

Description

technical field [0001] The invention relates to a new targeting carrier and the technical field of preparation thereof, in particular to mesoporous magnetic ferric iron tetroxide with the function of targeting drug transport, its preparation method and application. Background technique [0002] Nanocrystals have been widely used in magnetic fluids, microwave absorption, water treatment, photocatalysis, biomedicine, and bioseparation due to their superparamagnetism and high surface activity, and are becoming a research hotspot of magnetic nanomaterials. At present, the preparation methods of magnetic Fe3O4 nanocrystals mainly include precipitation method, solvothermal method, sol-gel method, microemulsion method, etc. ) Magnetic Fe prepared by these several methods 3 o 4 Although nanocrystals have certain differences in structure and magnetic properties, the prepared magnetic Fe 3 o 4 Nanocrystals are generally non-porous spherical or rhombohedral magnetic Fe 3 o 4 Nano...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G49/08A61K47/02A61P35/00
Inventor 陈秋云陶艮平
Owner JIANGSU UNIV
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