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Ion generation using wetted porous material

A technique for porous materials, ions, applied in methods using particle spectrometers, analytical materials, ion sources/guns, etc.

Active Publication Date: 2012-04-11
PURDUE RES FOUND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The problem with ESI is that to analyze many types of samples using ESI, the sample must first be prepared
However, the atmospheric pressure ionization techniques described above still require pneumatic assistance, continuous solvent flow, and high voltage power supplies to analyze samples

Method used

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  • Ion generation using wetted porous material
  • Ion generation using wetted porous material
  • Ion generation using wetted porous material

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0088] Example 1: Constructing MS Probes

[0089] Filter paper was cut into triangular pieces 10 mm long and 5 mm wide and used as nebulizers (Figure 1). Attach the copper clips to the paper, with the paper facing the inlet of the mass spectrometer (Figure 1). Install the copper clip on the 3D mobile stage to adjust its position accurately. A high voltage is applied to the copper clip and controlled by the mass spectrometer to generate analyte ions for mass spectrometric detection.

[0090] Apply the sample directly to the paper surface used as a sample purification and pre-concentration device. The filter paper allows the liquid sample to move through the hydrophilic network driven by capillary action and electric effect, and transports the liquid sample to the paper tip. Separation may occur during this transfer process. Upon application of a high voltage (~4.5 kV) to the paper surface, the sample solution was ejected from the paper tip and ionization and MS detection ...

example 2

[0092] Example 2: Generating a spray

[0093] The spray can be produced by applying a high potential to a moistened paper triangle. Place a paper triangle in front of the inlet of the LTQ with the tip of the paper triangle facing the inlet and separated from the inlet by 3 mm or more. Typically, 10 uL of sample solution was applied to wet the paper triangle. The solution may wet or saturate the paper or form a thin film layer of liquid on the surface of the paper. A high potential (3-5 kV) was applied between the paper triangle and the inlet of the mass spectrometer to generate an electric field, which induced charge accumulation on the liquid at the tip of the paper triangle. Increasing Coulombic forces break up the liquid to form charged droplets, and the solvent evaporates as the droplets splash from the paper tip to the mass spectrometer. Solvent removal using a paper sprayer does not require sheath gas, heat, or any other aids.

[0094] When fluid accumulates on a p...

example 3

[0095] Example 3: Probe Considerations

[0096] Probe material

[0097] A wide variety of porous materials can be tested to generate charged droplets for mass spectrometry. The material may be in the shape of a triangle with a tip, and the sample solution is then applied to the constructed probe. The data in this patent application document shows that any hydrophilic porous substrate can be used successfully, including cotton yarns, fabrics, plant tissue, and different kinds of paper. The porous network or microchannels of these materials provide sufficient space for liquid retention, and the hydrophilic environment enables liquid transport by capillary action. Hydrophobic porous substrates can also be successfully used with an appropriate selection of hydrophobic solvents.

[0098] After further investigation, six commercially available papers were selected and qualitatively tested to assess whether they could be used to detect an analyte. Filter paper and chromatograph...

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Abstract

The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent.

Description

[0001] Related applications [0002] The present invention claims U.S. Provisional Patent Application No. 61 / 174,215 filed April 30, 2009, U.S. Provisional Patent Application No. 61 / 246,707 filed September 29, 2009, and U.S. Provisional Patent Application No. 61 / 246,707 filed February 26, 2010. Priority to and benefit of U.S. Provisional Patent Application No. 61 / 308,332, each of which is incorporated herein by reference in its entirety. technical field [0003] The present invention generally relates to systems and methods for mass spectrometric analysis of samples. Background technique [0004] Mass spectrometry is a very sensitive analytical method used in important research and applications in analytical chemistry, especially in the life sciences. Electrospray ionization (ESI) is generally regarded as the best characterized and most efficient method for ionizing solution phase molecules. The method can be simply divided into three stages: droplet formation, droplet ev...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/00G01N27/62
CPCH01J49/16G01N1/00H01J49/04H01J49/168H01J49/0027H01J49/0431G01N33/6848H01J49/26H01J49/10H01J49/0031
Inventor Z·欧阳H·王尼古拉斯·E·马尼克罗伯特·格雷厄姆·库克斯Q·杨J·刘
Owner PURDUE RES FOUND INC
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