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Novel application of IL-1Ra (interleukin-1 receptor antagonist) and tumor treatment medicinal composition kit thereof

A chemotherapeutic drug and application technology, applied in the field of biomedicine, can solve problems such as immune function suppression and side effects, and achieve the effect of reducing acute damage to the thymus

Inactive Publication Date: 2012-03-14
SHANGHAI JIAO TONG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is to solve the problem of side effects of immunosuppression during tumor radiotherapy and / or chemotherapy

Method used

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  • Novel application of IL-1Ra (interleukin-1 receptor antagonist) and tumor treatment medicinal composition kit thereof
  • Novel application of IL-1Ra (interleukin-1 receptor antagonist) and tumor treatment medicinal composition kit thereof
  • Novel application of IL-1Ra (interleukin-1 receptor antagonist) and tumor treatment medicinal composition kit thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Example 1.5-Aza chemotherapy damage to thymus and rHuIL-1Ra preventive administration of thymus protection

[0088] 3 mg / kg / day rHuIL-1Ra was continuously injected 5 days before chemotherapy, 100 mg / kg 5-Aza was injected intraperitoneally within 24 hours of the last protein administration (recorded as day 0), and on day 0 (injection of 5-Aza Before), 1.5 days, 3 days, 7 days, 11 days, and 14 days, the thymus of mice in the control group and the treatment group were collected respectively, and the changes of thymus index and H&E staining of thymus pathological sections were observed.

[0089] The experimental results showed that 5-Aza had obvious toxic and side effects on the thymus of mice, and caused the thymus injury and repair process caused by chemotherapy. On day 1.5, day 3, and day 7 after chemotherapy, the thymus index of mice in the control group (NS) and mice in the treatment group (rHuIL-1Ra) decreased sharply. On the 3rd day, the thymus index of mice in the ...

Embodiment 2

[0096] Example 2. rHuIL-1Ra preventive administration protects thymus damage and promotes its repair

[0097] The experimental animals were 4-week-old BALB / c male mice, and the experiment consisted of a normal saline control group and a rHuIL-1Ra protein administration group. The dose of rHuIL-1Ra was 3 mg / kg, and it was injected every 12 hours for 5 days before chemotherapy. The injection method was subcutaneous injection, and the mice injected with the same volume of non-pyrogenic saline (NS) were used as the control group. Within 24 hours of the last protein injection, 5-Aza 100mg / kg was injected intraperitoneally once. A group of mice were sacrificed on day 0 (before injection of 5-Aza), day 7, and day 11, and the thymus index, total number of thymocytes, proportion of thymocyte subsets, thymocyte proliferation, and peripheral blood initial Changes in T cells.

[0098] 2.1 Effect of rHuIL-1Ra on thymus index and total number of thymocytes

[0099] The experimental desig...

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Abstract

The invention belongs to the technical field of biological medicines, in particular relates to novel application of IL-1Ra (interleukin-1 receptor antagonist), and discloses application of the IL-1Ra protein (shown in the specification) in preparing a medicament for treating or protecting thymic lymphocyte injury or peripheral T lymphopenia caused by radiotherapy and / or chemotherapeutic drugs. The protein can effectively reduce, treat or prevent acute thymus injury and / or immunological function repression side effect caused by radiotherapy and / or chemotherapeutic drugs, and is expected to be a novel choice for clinical tumor treatment in the future.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a new application of IL-1Ra and a combination medicine box for treating tumors. Background technique [0002] In recent years, with the advancement of medicine, the average life expectancy of modern humans has increased to 80 years, and the incidence of tumors has increased significantly. Tumors and cardiovascular and cerebrovascular diseases have become two major killers of human health, and the high incidence and high mortality of tumors have become important factors that threaten human health. [0003] With the study of tumor pathogenesis, people have a further understanding of tumors. Studies have shown that tumor cells are abnormal cells that grow out of control and will migrate from the original site of the tumor to other sites. If the spread of the tumor cannot be controlled, the tumor will invade the vital organs of the human body, cause organ failure, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/20A61K45/00A61P35/00A61P43/00
Inventor 韩伟俞雁于鸿晶
Owner SHANGHAI JIAO TONG UNIV
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