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Preparation technique of wound dressing

A preparation process and technology for wound dressings, applied in the field of preparation of medical dressings, can solve the problems of limited drug-carrying properties of dressings, inability to meet industrial benefits, and inability to completely eliminate adhesion, and achieve good operation controllability, high tensile strength, Optimum effect of external contamination and bacterial entry

Inactive Publication Date: 2012-01-25
AMED
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, for example, the Chinese patent application 200810122438.1 published on October 29, 2008 provides a method for preparing a medical hydrogel bed dressing, but because of the use of radiation to achieve polymerization, it cannot meet industrial benefits. Another example is the 2005 The publication number published on January 12 is the patent application CN1562382A titled "hydrogel type wound dressing containing polyurethane aqueous emulsion and its preparation method", all of which provide hydrogel as a matrix for medical dressings, but the above dressings contain The drug properties are limited, and the adhesion cannot be completely eliminated

Method used

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  • Preparation technique of wound dressing
  • Preparation technique of wound dressing
  • Preparation technique of wound dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1 The specific preparation process of this wound dressing is as follows:

[0031] Using acrylic amide monomers and acrylic sulfonate monomers as cross-linking polymerization raw materials, glycerin as thickener and plasticizer, and difunctional esters with unsaturated double bonds as cross-linking The agent is polymerized and cross-linked by ultraviolet light to obtain a hydrogel material, and the hydrogel material is carried in a Teflon container, and then irradiated with ultraviolet light to obtain the wound auxiliary material.

[0032] The wound auxiliary material has a great swelling degree of 5000%. The surface of the hydrogel material is sticky. After absorbing water, its surface is non-sticky and will not stick to the wound. Keep trauma wounds in an optimal healing environment.

Embodiment 2

[0033] Embodiment 2 The specific preparation process of this wound dressing is as follows:

[0034] The material with the following weight ratio is used as raw material:

[0035]

[0036] First mix acrylic sulfonate monomers, acrylic amide monomers, and unsaturated double bond difunctional ester monomers, and add a photoinitiator to carry out cross-linking under ultraviolet light. Copolymerize to obtain hydrogel, add glycerol to the hydrogel and mix, and the mixed hydrogel is coated on the polyurethane elastic film for bonding to obtain the wound dressing.

[0037] After testing, the swelling degree of the wound dressing is about 5100%, the surface of the hydrogel is viscous, and the initial force can reach 1000nt / m 2 , the moisture absorption rate reaches 0.1ml / cm 2 / day, the gas exchange rate is 10000cm 3 / m 2 / day / atm. After absorbing water, the surface of the hydrogel is non-sticky and will not stick to wound tissue; the hydrogel has better tensile strength, and it...

Embodiment 3

[0038] Embodiment 3 The specific preparation process of the wound dressing is as follows:

[0039] The material with the following weight ratio is used as raw material:

[0040]

[0041]

[0042] The above-mentioned raw materials and drug components are mixed, coated on the polyurethane elastic film, and then cross-linked and polymerized by ultraviolet light, and the hydrogel is used as a drug carrier to obtain the wound dressing. The preparation process of the wound dressing is reasonable, and the operation is good in controllability. It can realize the high tensile strength of the wound dressing and the non-adhesive characteristics of the wound wound. It has good water absorption performance and has better characteristics of preventing external pollution and bacterial entry. The hydrogel used in the wound material can be used as a drug carrier to realize the drug. Embedding and carrying function. In a specific application, a hydrophilic layer can be coated on the sur...

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Abstract

The invention relates to a preparation technique of a wound dressing, which is characterized by comprising steps as follows: acrylic sulfonate monomers and acrylic amide monomers are used as crosslinking polymerization materials, glycerol is used as a plasticizer, and unsaturated double-bond bifunctional ester monomers are used as a crosslinking agent; ultraviolet polymerization crosslinking is carried out to obtain an aquagel material; and the aquagel is combined with a substrate to obtain the wound dressing. The preparation technique of the wound dressing is reasonable, and has good operational controllability. The invention can implement high tensile resistance of the wound dressing and no adhesion characteristic of the wound; the wound dressing has good water absorptivity, has good characteristics of preventing external contamination and bacteria entry; and the aquagel used by the wound dressing can also be used as a pharmaceutical vector to perform the functions of embedding and carrying drugs.

Description

technical field [0001] The invention belongs to the technical field of preparation of medical dressings, and in particular relates to a preparation process of wound dressings capable of maintaining the wound healing environment, shortening the healing time, antibacterial and reducing the chance of infection. Scientifically Administered Wound Dressings. Background technique [0002] According to scientific and statistical reports in recent years, the demand for trauma in the global trauma market is increasing, especially surgical trauma, the total number of which has exceeded 100 million per year, and is showing a growing trend year by year. The number of wounds and lacerations caused by accidents is about 20 million per year, and the number of burns and scalds is about 10 million per year; ulcerative wounds caused by chronic diseases, diabetes, and aging population have exceeded 3 Tens of millions of visitors per year. [0003] Due to the demand for treatment and the popul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/26A61L15/28A61L15/32A61K47/34C08F220/00C08F2/48C08K5/053
Inventor 林祖泰
Owner AMED
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