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Preparation method of sulfamethoxazole residue freeze-dried powder standard sample in carp muscle

A technology of sulfamethoxazole and standard samples, which is applied in the field of preparation of standard samples of sulfamethoxazole residue matrix freeze-dried powder in carp muscle, can solve the problem that cannot represent the existence of target analytes and affect the reliability and validity of results , can not represent the target analyte and other problems, achieve significant economic value and market competitiveness, uniform and stable samples, and convenient transportation

Inactive Publication Date: 2012-01-18
时文春
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Problems solved by technology

At present, the standard substances used for the detection of sulfonamide drug residues are mainly various pure standard samples, and the quality control of the detection is mainly performed by adding various pure standard substances to the samples for detection and analysis. This analysis method cannot represent the target analyte The state that actually exists in vivo, that is, it cannot represent the "internalized" state of the target analyte in the animal
The standard sample obtained in this way is not a real physical standard sample. Because the combination of the target object and the matrix is ​​not completely consistent with the real test sample, the results of extraction, purification, etc. are quite different from the daily analysis samples, thus affecting the accuracy of the results. Reliability and Validity

Method used

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  • Preparation method of sulfamethoxazole residue freeze-dried powder standard sample in carp muscle
  • Preparation method of sulfamethoxazole residue freeze-dried powder standard sample in carp muscle
  • Preparation method of sulfamethoxazole residue freeze-dried powder standard sample in carp muscle

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Embodiment 1

[0013] Embodiment 1, a method for preparing a standard sample of sulfamethoxazole residual freeze-dried powder in carp muscle. This embodiment takes the control target content level of 200-300ug / kg as an example, and its specific steps are as follows:

[0014] (1) Selection of experimental animals: Live carps purchased from the market are required to be of uniform size and average weight of about 2 kg. It should be confirmed that the sample does not contain sulfamethoxazole, and random sampling should be carried out. After the test confirms that the sample is negative, it should be fed. After the negative samples were fed for 2 days at 20°C-25°C, the injured and unhealthy carps were removed;

[0015] (2) Drug breeding addition: Add medical sulfamethoxazole tablets to fish ponds, first crush the tablets and dissolve them in water, add drugs according to the amount of breeding water to make the concentration of ciprofloxacin in the water about 1000ug / L, monitor in real time Dete...

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Abstract

The invention discloses a preparation method of sulfamethoxazole residue freeze-dried powder standard sample in carp muscle, which takes the carp as a research object to research a carp muscle material object standard sample containing sulfamethoxazole of certain concentration in a breeding mode of adding sulfamethoxazole. The key production control technology of the material object standard sample disclosed by the invention is mastered and comprises content level, evenness, stability, constant value and the like control, and the standard sample is produced and prepared in a standardization and scale mode. The standard sample is used for detection quality control and detection capability evaluation for residue of veterinary drug in animal-derived food and has an important meaning for food safety detection.

Description

technical field [0001] The invention belongs to the technical field of animal food matrix standard substances for detection of veterinary drug residues, in particular to a method for preparing standard samples of sulfamethoxazole residue matrix freeze-dried powder in carp muscle. [0002] Reference material is a measurement standard with accurate value. It is used to study and evaluate measurement methods, ensure the consistency and comparability of measurement results, and ensure the differences between countries, departments, commodity exchanges or technical exchanges, and production process control. The comparability and consistency of analytical results between times is materially important. [0003] Reference Material (RM for short) includes pure chemical substances and physical standard samples with certain physical and chemical properties Background technique [0004] Sulfamethoxazole is a typical sulfonamide drug, the structural formula is 3-p-aminobenzenesulfonamid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/28G01N1/42
Inventor 颜显辉何平时文春崔嘉李大栓
Owner 时文春
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