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Medicinal composition for treating cardiovascular diseases and preparation method thereof

A composition and cardiovascular technology, applied in the field of pharmaceutical composition and its preparation, can solve the problems of failing to reduce long-term cardiac end-point events and the incidence of patients, so as to improve myocardial hypoxia resistance and improve vascular endothelial function , high safety effect

Active Publication Date: 2014-06-18
吉林省集安益盛药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, recent large-scale clinical studies have shown that interventional therapy did not reduce the incidence of rehospitalization of patients due to symptom recurrence, nor did it reduce the occurrence of long-term cardiac endpoints

Method used

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  • Medicinal composition for treating cardiovascular diseases and preparation method thereof
  • Medicinal composition for treating cardiovascular diseases and preparation method thereof
  • Medicinal composition for treating cardiovascular diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] Embodiment 1: Capsules

[0105] Take the dried American ginseng stems and leaves and place them in a multi-functional traditional Chinese medicine extraction tank, add purified water according to the mass ratio of dried American ginseng stems and leaves to purified water at 1:8, 1:6 and 1:6, and extract for 2.5 hours, After 2h and 1.5h, the extracts were roughly filtered three times, and the combined filtrates were introduced into the alcohol precipitation tank, left to cool for 24 hours, the supernatant was absorbed, filtered through gauze, and then entered into a D101 macroporous resin column to absorb saponins, and the column flow rate was controlled. 2-3L / min, after the resin is saturated, wash with purified water until colorless, then elute with 80% V / V ethanol, control the column flow rate at 3-5L / min, collect the eluate, and import it into a vacuum concentration recovery tank In the process, recover ethanol, collect the concentrated solution, put the concentrated...

Embodiment 2

[0110] Embodiment 2: tablet

[0111] Take the dried American ginseng stems and leaves and put them in a multi-functional traditional Chinese medicine extraction tank, add purified water according to the mass ratio of dried American ginseng stems and leaves to purified water at 1:12, 1:9 and 1:8, and extract for 2 hours and 1.5 hours respectively. h, 1h, three extractions were coarsely filtered, the combined filtrates were introduced into an alcohol precipitation tank, left to cool for 20 hours, the supernatant was absorbed, filtered through a gauze, and then entered into a D101 macroporous resin column to absorb saponins, and the column flow rate was controlled at 1 ~2L / min, after the resin is saturated, wash with purified water until colorless, then elute with 75% V / V ethanol, control the column flow rate at 2~4L / min, collect the eluate, and import it into a vacuum concentration recovery tank , recover ethanol, collect the concentrated solution, put the concentrated solution ...

Embodiment 3

[0116] Embodiment 3: Granules

[0117] Take 56.5 g of the total saponin extract of American ginseng stems and leaves and 40 g of ginkgo leaf extract prepared in Example 1, mix well, add conventional auxiliary materials, and make granules according to conventional processes.

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PUM

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Abstract

The invention discloses a medicinal composition for treating cardiovascular diseases and a preparation method thereof. The medicinal composition is prepared from the following active pharmaceutical ingredients: ginseng stem and leaf, ginkgo leaf, total saponin extract of ginseng stem and leaf, and ginkgo leaf extract. The medicinal composition can effectively resist rat infarction and myocardial ischemia injury of acute myocardial infarction, reduce the myocardial infarction area, enhance the hypoxia resistance of cardiac muscles, improve the function of vascular endothelium and resist arterial thrombosis. The synergic experiment indicates that the active pharmaceutical ingredients (ginseng stem and leaf and ginkgo leaf) medicinal composition have an synergic action, and have much better effect as compared with single ginseng stem and leaf or ginkgo leaf. The medicinal composition has the advantages of low toxicity, high safety and high stability.

Description

field of invention [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition for treating cardiovascular diseases and a preparation method thereof. Background technique [0002] Angina pectoris of coronary heart disease is a clinical syndrome caused by temporary myocardial ischemia and hypoxia, with episodic chest pain or chest discomfort as the main manifestation. Angina pectoris often occurs when labor, emotional agitation or other factors increase myocardial oxygen consumption. The pain can often radiate to the left shoulder, neck pharynx or mandible, and can be relieved within a few minutes by rest or nitroglycerin. During the onset of angina pectoris, the electrocardiogram often shows temporary ST segment changes or accompanied by T wave changes, and coronary angiography shows narrowing of the coronary artery lumen. [0003] In the 1980s, the development and popularization of interventio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/258A61P9/00A61K36/16
Inventor 尹笠佥殷惠军史大卓张益胜徐芳菲单强
Owner 吉林省集安益盛药业股份有限公司
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