Preparation method of artificial bone scaffold of porous bioceramic microspheres

Abstract

The invention discloses a method for preparing an artificial bone scaffold of porous bioceramic microspheres. A three-dimensional CAD model established according to individual characteristics is imported into a three-dimensional printer, and the three-dimensional printer sprays biological adhesives to realize the preparation of bioceramics. In order to overcome the disadvantages of pollution and poor mechanical properties due to sintering in the preparation process of the prior art porous ceramic stent, the present invention provides an improved bio-adhesive. By controlling the atomization and spraying parameters, different proportions of bio-adhesive, The curing accelerator and the thickening and toughening modifier are fully mixed to achieve the effect of controllable mechanical properties and controllable curing time. The improved adhesive has the advantages of high bonding strength, high toughness and good compatibility with human body fluids, and avoids sintering during the preparation process. The invention is made by a rapid prototyping method, which reduces the cost and time of making molds, improves the manufacturing efficiency and reduces the manufacturing cost.

Description

[0001] Field: [0002] The invention relates to a preparation method of an artificial bone scaffold based on bioceramic microspheres. It particularly relates to the preparation of an active bioceramic microsphere artificial bone scaffold with controllable mechanical properties by using an improved bioadhesive through a rapid prototyping method. Background technique: [0003] Human bones have a certain ability to regenerate and self-repair, but for large bone defects caused by trauma, infection, tumors, and developmental deformities, bone self-repair alone cannot heal, and bone transplantation is required. The transplant materials mainly include autologous bone, allogeneic bone and synthetic materials. The effect of autologous bone tissue transplantation is very good, but there are disadvantages such as a very limited quantity, the need for a second operation, and certain complications in the bone harvesting area. Although allograft transplantation does not require two operati...

AI Technical Summary

Problems solved by technology

[0009] The organic binder for preparing the scaffold needs to be burned at high temperature, which also prolongs the preparation time of the scaffold, increases the cost, and increases the chance of bioceramic particles being contaminated

Moreover, the prepared porous bioceramic scaffold has a dense external structure, and it is difficult for nutrient solution to be transported in it.

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