Experimental device for changing toad heart afterload

Abstract

The invention relates to an experimental device for changing toad heart afterload, and mainly solves the technical difficulty that the existing experimental device does not conform to the physiological status and clinical practices of a body. The experimental device comprises an arterial cannula, a main output pipe, a main pipe, a main pipe sleeve, side pipes, side pipe sleeves, output pipes and plugs. In use, the two ends of the main output pipe are respectively connected with the M ends of the arterial cannula and the main pipe, and the output pipes of different sizes can be optionally connected with or dismounted from the corresponding side pipes. The output quantity of a certain output pipe is measured, when required, by firstly connecting the output pipes and the corresponding side pipes and simultaneously closing all of the other side pipes with the corresponding plugs. The experimental device provided by the invention uses the output pipes of different sizes to manifest the degree of arteriostenosis and reflect the change in peripheral blood resistance and the change in heart afterload. The experimental device has the characteristics of reasonable and compact structure and accurate measurement, and is simple for operation.

Description

Technical field: [0001] The invention relates to a frog heart perfusion experimental device for functional science of basic medicine, in particular to an experimental device for changing toad heart afterload. Background technique: [0002] Factors affecting heart function and treatment of heart failure are routine experimental items in basic medical functional experiments in all medical colleges. In this experiment, the effect of afterload changes on toad heart function is one of the important observation indicators. At present, the frog heart perfusion experimental devices used in various medical schools are not the same, but the method of changing the cardiac afterload is basically the same, that is, the increase of peripheral resistance is reflected by raising the height of the output tube. The issue is: [0003] (1) By raising the height of the output tube, that is, through the external atmospheric pressure and the gravity of the fluid in the lumen to reflect the increa...

AI Technical Summary

Problems solved by technology

[0003] (1) By raising the height of the output tube, that is, through the external atmospheric pressure and the gravity of the fluid in the lumen to reflect the increase of peripheral resistance and the increase of cardiac afterload, the principle does not conform to the physiological state of the body, because from the perspective of clinical medicine Said that the increase in peripheral resistance results from the narrowing of the arterial lumen (arterospasm or atherosclerosis), which eventually leads to an increase in afterload

[0004] (2) After the application of cardiotonic drugs, sometimes the height of the output tube has reached the maximum range (30cm) that can be raised, but there is still no sign of heart failure, and therefore complete experimental records and experimental results cannot be obtained. As a result, the experimental purpose could not be achieved

[0005] (3) In each experiment, it is necessary to move the output tube up and down on its fixing bracket more than ten times or even dozens of times to change the height of the output tube repeatedly. This operation is not only time-consuming and laborious, but also easily causes the adjustment parts wear and tear or even failure

Moreover, because new adjustment parts need to be replaced from time to time, the increase in experiment cost

[0006] (4) According to the needs, the operation of changing the height of the output tube (changing the afterload) in the experiment needs to be repeated more than ten times or even dozens of times, and each operation is likely to cause distortion of the posterior vena cava cannula and the arterial cannula. Lead to poor channel, experiment interruption or even failure

[0007] (5) In order to ensure the lifting range of the output tube, the length of the output tube is designed to be 30cm (same height as the output tube fixing bracket), too long output tube and excessive frequent changes of the output tube will easily cause waste of nutrient solution

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