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Method for preparing gelatin/polycaprolactone composite nanometer fiber membrane through electrostatic spinning

A technology of composite nanofibers and polycaprolactone, which is applied in fiber processing, conjugated synthetic polymer artificial filaments, cellulose/protein conjugated artificial filaments, etc., can solve the time-consuming problem of nanofiber membranes (several hours or Longer time, adverse effects on composite nanofiber morphology and other properties, failure to achieve complementary advantages, etc., to achieve the effect of continuous nanofiber industrial production, low cost, and solve the problem of phase separation

Inactive Publication Date: 2011-11-16
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, gelatin is a natural biological material with good hydrophilicity and cell affinity, while polycaprolactone is a synthetic polymer material and is a hydrophobic material. When they are stirred in a co-solvent After standing for a few hours, phase separation will occur [Zhang YZ, et al. Nanotechnology 2006, 17(3): 901-908], because it takes a long time to prepare a nanofiber membrane with a certain thickness by electrospinning (several hours or longer), which means that the content of the nanofiber components obtained in the long-term preparation process changes, which also has an adverse effect on the morphology and other properties of the composite nanofibers, which will lead to failure to achieve uniformity The purpose of blending, it is impossible to realize their complementary advantages
The subtle but important problem of their phase separation during spinning has been rarely observed

Method used

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  • Method for preparing gelatin/polycaprolactone composite nanometer fiber membrane through electrostatic spinning
  • Method for preparing gelatin/polycaprolactone composite nanometer fiber membrane through electrostatic spinning
  • Method for preparing gelatin/polycaprolactone composite nanometer fiber membrane through electrostatic spinning

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Take 0.5g gelatin and 0.5g polycaprolactone with an electronic analytical balance and dissolve them in 10ml of trifluoroethanol, stir until completely dissolved, and obtain gelatin / polycaprolactone with a concentration of 10% (g / ml) For the spinning solution, add 10 ul of acetic acid to the solution, stir for 10-20 minutes to make the solution change from cloudy to clear, and obtain the gelatin / polycaprolactone spinning solution.

[0030] figure 1 It is a black and white photo of gelatin / polycaprolactone spinning solution without acetic acid and acetic acid added after standing for 12 hours. In the photos, it can be clearly seen that a large amount of precipitation occurred after the spinning solution without acetic acid was left standing.

[0031](2) Select a 10ml syringe and a needle with an inner diameter of 1.2mm to extract the gelatin / polycaprolactone spinning solution and fix it on an electrospinning device for electrospinning. The parameters are: voltage 9kv,...

Embodiment 2

[0034] (1) Take 0.5g gelatin and 0.5g polycaprolactone with an electronic analytical balance and dissolve them in 10ml of trifluoroethanol, stir until completely dissolved, and obtain gelatin / polycaprolactone with a concentration of 10% (g / ml) For the spinning solution, add 20ul of acetic acid to the solution and stir for 10-20min until the solution turns from turbid to clear to obtain a gelatin / polycaprolactone spinning solution.

[0035] (2) Choose a 10ml syringe and a needle with an inner diameter of 1.2mm to extract the gelatin / polycaprolactone spinning solution and fix it on the electrospinning device for electrospinning. The electrospinning parameters are: voltage 13kv, acceptance distance 15cm, injection rate 2ml / h, temperature 30°C, relative humidity 50%. Using aluminum foil as a receiving device, spinning for 5 hours to obtain a gelatin / polycaprolactone composite nanofiber membrane. The collected composite fiber membranes were dried in a vacuum oven for 24 h. Figur...

Embodiment 3

[0038] (1) Take 0.5g gelatin and 0.5g polycaprolactone with an electronic analytical balance and dissolve them in 10ml of trifluoroethanol, stir until completely dissolved, and obtain gelatin / polycaprolactone with a concentration of 10% (g / ml) For the spinning solution, add 30ul of acetic acid to the solution and stir for 10-20min until the solution turns from turbid to clear to obtain a gelatin / polycaprolactone spinning solution.

[0039] (2) Choose a 10ml syringe and a needle with an inner diameter of 1.2mm to extract the gelatin / polycaprolactone spinning solution and fix it on the electrospinning device for electrospinning. The electrospinning parameters are: voltage 12kv, acceptance distance 12cm, injection rate 2ml / h, temperature 25°C, relative humidity 40%. Using aluminum foil as a receiving device, spinning for 5 hours to obtain a gelatin / polycaprolactone composite nanofiber membrane. The collected composite fiber membranes were dried in a vacuum oven for 24 h.

[004...

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Abstract

The invention relates to a method for preparing a gelatin / polycaprolactone composite nanometer fiber membrane through electrostatic spinning, comprising the steps of: (1) mixing gelatin with polycaprolactone, adding the mixture into trifluoroethanol or hexafluoroisopropanol, stirring, adding acetic acid and stirring till the solution is transparent so as to obtain a gelatin / polycaprolactone spinning solution; and (2) extracting the gelatin / polycaprolactone spinning solution, fixing on an electrostatic spinning device to carry out electrospinning, collecting fiber membranes, and drying in vacuum to obtain the gelatin / polycaprolactone composite nanometer fiber membrane. The method provided by the invention has the advantages of quickness, simpleness, convenience, low cost and good spinnability; the prepared composite nanometer fibers have smaller diameter and very good mechanical property and are suitable for batch preparation and mass production of the gelatin / polycaprolactone composite nanometer fiber membrane.

Description

technical field [0001] The invention belongs to the field of preparation of composite nanofiber membranes, in particular to a method for preparing gelatin / polycaprolactone composite nanofiber membranes by electrospinning. Background technique [0002] In recent years, the preparation of one-dimensional nanofibers by electrospinning technology has become a hotspot in the research of nanomaterials, especially in the bionic construction of tissue engineering scaffolds, which has very broad development and application prospects. The materials that can be electrospun into tissue engineering scaffolds are divided into natural materials, synthetic polymer materials and their composites. Natural materials include collagen, gelatin, silk, spider silk, sodium alginate, chitin and their derivatives; Molecular materials are mainly some degradable materials including polycaprolactone (PCL), polyglycolic acid (PGA), polylactic acid (PLA), polylactic-co-glycolic acid (PLGA) and so on. Nat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/72D01D5/00D01F8/02D01F8/14
Inventor 张彦中冯蓓袁卉华彭红菊
Owner DONGHUA UNIV
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