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Chinese medicinal composition for resisting anoxia and fatigue and preparation method thereof

An anti-fatigue and composition technology, which is applied in the field of medicine, can solve the problems of complex preparation process, inconvenient portability of oral liquid, and slow onset of tablets, and achieve simple formula and preparation process, increase bioavailability, and improve drug absorption. Effect

Inactive Publication Date: 2011-11-02
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Most of the currently developed Rhodiola preparations are capsules, tablets, oral liquids and dripping pills. Pills have quick-acting characteristics, but the preparation process is complicated and the stability is poor, which cannot meet the needs of emergencies

Method used

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  • Chinese medicinal composition for resisting anoxia and fatigue and preparation method thereof
  • Chinese medicinal composition for resisting anoxia and fatigue and preparation method thereof
  • Chinese medicinal composition for resisting anoxia and fatigue and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Weighing: Rhodiola rosea extract 10g, borneol 0.006g, β-cyclodextrin 0.036g, direct-pressed lactose 39.128g, microcrystalline cellulose 43.2g, low-substituted-hydroxypropyl cellulose 4.8g, cross-linked polymer Vitone 6g, citric acid 6.3g, aspartame 0.36g, magnesium stearate 0.6g, silicon dioxide 0.6g, mint flavor 3.6g, sodium bicarbonate 5.25g, orange flavor 0.12g.

[0024] Described medicine adopts following steps to make (as figure 1 shown):

[0025] ⑴Preparation of Rhodiola rosea extract: Take the Rhodiola rosea medicinal material of the above weight, crush it into a coarse powder, add 10 times and extract 3 times with 85% ethanol under reflux, each time for 2 hours, filter, combine the filtrate, reduce pressure (- 0.6~-0.7Mpa) to concentrate and recover ethanol, the temperature is 65~67℃. The heat specific gravity is 1.02 extractum; it is adsorbed by AB-8 macroporous resin, eluted with 0%, 40%, 95% ethanol gradient, and 40% ethanol eluate is collected, spray-drie...

Embodiment 2

[0030] Weighing: Rhodiola rosea extract 12g, borneol 0.009g, β-cyclodextrin 0.036g, direct-pressed lactose 39.125g, microcrystalline cellulose 41.2g, low-substituted-hydroxypropyl cellulose 4.8g, cross-linked polydimensional Ketone 6g, citric acid 7.3g, aspartame 0.36g, magnesium stearate 0.6g, silicon dioxide 0.6g, mint essence 3.6g, sodium bicarbonate 4.25g, orange essence 0.12g.

[0031] The medicine is made by following steps:

[0032] ⑴Preparation of Rhodiola rosea extract: take the Rhodiola rosea medicinal material of the above weight, crush it into a coarse powder, add 9 times and extract it once with 65% ethanol under reflux, for 1 hour each time, filter, combine the filtrates, and reduce pressure (- 0.6~-0.7Mpa) to concentrate and recover ethanol, the temperature is 65~67℃. The heat specific gravity is 1.05 extractum; it is absorbed by AB-8 macroporous resin, eluted with 0%, 40%, 95% ethanol gradient, and 40% ethanol eluate is collected, spray-dried, and the sem...

Embodiment 3

[0037] Weighing: Rhodiola rosea extract 11g, borneol 0.008g, β-cyclodextrin 0.064g, direct-pressed lactose 39.098g, microcrystalline cellulose 42.2g, low-substituted-hydroxypropyl cellulose 5.8g, cross-linked poly Vitone 5g, citric acid 5.3g, aspartame 0.36g, magnesium stearate 0.6g, silicon dioxide 0.6g, mint flavor 3.6g, sodium bicarbonate 6.25g, orange flavor 0.12g.

[0038] The medicine is made by following steps:

[0039] ⑴Preparation of Rhodiola rosea extract: take the above-mentioned Rhodiola rosea medicinal material, crush it into coarse powder, add 8 times and extract twice with 95% ethanol under reflux, each time for 1.5 hours, filter, combine the filtrates, reduce pressure (-0.6 ~-0.7Mpa) to concentrate and recover ethanol, the temperature is 65~67℃. The heat specific gravity is 1.10 extractum; absorbed by AB-8 macroporous resin, eluted with 0%, 40%, 95% ethanol gradient, collected 40% ethanol eluate, spray dried, and the semi-finished product was crushed, sieved, ...

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Abstract

The invention discloses a Chinese medicinal composition for resisting anoxia and fatigue and a preparation method thereof. The Chinese medicinal composition is prepared by adding excipients such as a disintegrant, a flavoring agent and the like into rhodiola rosea and borneol which are taken as raw materials. The content of rosavin and salidroside contained in a rhodiola rosea extract obtained by the method is improved; and the process is simple. Pharmacodynamic experiment results of the Chinese medicinal composition show that the medicine has remarkable effects of resisting anoxia and fatigue. The Chinese medicinal composition and the preparation method have the advantages that: the formula is simple, the preparation process is simple, and the medicine is convenient to use and has no toxic or side effect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a traditional Chinese medicine composition for treating anti-hypoxia and anti-fatigue and a preparation method thereof. Background technique [0002] The plants of the genus Rhodiola (Rhodiola L.) in the Sedum family are perennial herbs or subshrubs, and there are about 70 species in my country. With the deepening of modern research in the past 40 years, Rhodiola has become a new force in the field of environmental adaptability drugs discovered in my country after ginseng and eleuthero. The anti-hypoxia and anti-fatigue effects of Rhodiola have been confirmed by a large number of experiments and clinical verification, and are recognized. It is generally believed that the main active ingredients of Rhodiola rosea for anti-hypoxia and anti-fatigue are salidroside and its aglycone tyrosol, which belongs to phenethyl glycosides. Therefore, the current rhodiola medicinal materials a...

Claims

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Application Information

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IPC IPC(8): A61K36/41A61K47/38A61K47/48A61P39/00A61P39/06A61K31/045
Inventor 姚敏娜汤海峰周晓明马宁张伟田向荣张红霞张登武文爱东杨志福
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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