Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Garcinia derivative, method for preparing same and pharmaceutical application thereof

一种药学、化合物的技术，应用在藤黄属衍生物及其制备领域，能够解决抗肿瘤活性下降、不利工业生产、不具备成药性特征等问题，达到活性优、结构简单、强抗肿瘤细胞增殖的效果

Inactive Publication Date: 2011-10-12
CHINA PHARM UNIV
View PDF0 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the large molecular weight of gambogic acid, adding corresponding groups in the structural modification may lead to unsatisfactory druggability, and the source of gambogic acid depends on the extraction and separation of natural products, which is not conducive to industrial production
There are relevant literatures reporting that its structure simplifies II, and through anti-pharmacological tests, it is found that the anti-tumor activity is much lower than that of gambogic acid, and it does not have the characteristics of druggability

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

Embodiment 2

Embodiment 3

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the field of pharmaceutical chemistry, in particular to a garcinia derivative(I), a method for preparing the same and pharmaceutical application thereof. The definitions of R1 and R2 are specified in the description. The derivative of the invention is a structure-simplified analogue of gambogic acid compounds, has the anti-tumor effect and can be used for preparing anti-tumor medicaments.

Description

technical field The invention relates to the field of medicinal chemistry, in particular to a class of Garcinia derivatives, a preparation method thereof and an application in pharmacy. The derivative is a structure simplification of gambogic acid compound, has antitumor effect and can be used for preparing antitumor drugs. Background technique The natural product, gambogic acid, was first extracted from the garcinia resin of the genus Garcinia, and it is an important anti-tumor active ingredient in the garcinia resin. Studies have shown that gambogic acid can selectively kill various tumor cells without affecting the normal hematopoietic system and immune function. Gambogic acid can also bind to a variety of proteins related to tumorigenesis and invasion to induce apoptosis, and can be used as an effective apoptosis inducer for various tumor lines. The structural formula of gambogic acid is as follows: Due to the large molecular weight of gambogic acid, adding correspon...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/08A61K31/352A61P35/00
CPCC07D493/10A61P35/00
Inventor 尤启冬汪小涧杨倩卢娜林昌军郭青龙
Owner CHINA PHARM UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com