Pharmaceutical composition containing fasudil and sildenafil, and preparation method and application thereof

A technology of fasudil and sildenafil, applied in the field of pharmacy, can solve the problems of complicated treatment and unsatisfactory effects

Active Publication Date: 2011-10-05
TIANJIN CHASE SUN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] Pulmonary hypertension, common in adolescent patients, is an extremely nasty disease that is now complicated and less effective in treatment
There are many treatments for pulmonary hypertension, but there is no specific treatment. The treatment of pulmonary hypertension mainly promotes vasodilation, inhibits cell proliferation and induces apoptosis in the pulmonary artery wall through prostacyclin, endothelin and nitric oxide. for the purpose of treatment

Method used

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  • Pharmaceutical composition containing fasudil and sildenafil, and preparation method and application thereof
  • Pharmaceutical composition containing fasudil and sildenafil, and preparation method and application thereof
  • Pharmaceutical composition containing fasudil and sildenafil, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083]

[0084] Preparation:

[0085] After crushing the prescribed amount of fasudil and sildenafil through a 120-mesh sieve, mix them evenly with low-substituted hydroxypropyl cellulose, lactose, microcrystalline cellulose, starch, and calcium hydrogen phosphate that have passed through an 80-mesh sieve, and add Soft material made from 10% starch pulp, granulated through a 24-mesh sieve, ventilated and dried at 55°C, granulated through a 20-mesh sieve, mixed evenly with magnesium stearate, compressed into tablets to obtain compound tablet cores.

Embodiment 2

[0087]

[0088]

[0089] Preparation:

[0090] Grind the prescribed amount of Fasudil through a 100-mesh sieve, mix evenly with low-substituted hydroxypropyl cellulose, lactose, and microcrystalline cellulose that have passed through an 80-mesh sieve, and add 2% hydroxypropyl methylcellulose as a soft material , granulated through a 24-mesh sieve, ventilated and dried at 55°C, granulated through a 20-mesh sieve and mixed evenly with magnesium stearate to obtain Granule 1 for later use.

[0091] Grind the prescribed amount of sildenafil through a 100-mesh sieve, mix evenly with low-substituted hydroxypropyl cellulose, lactose starch, and microcrystalline cellulose that have passed through an 80-mesh sieve, add 2% hydroxypropyl methylcellulose to make soft material, granulated through a 24-mesh sieve, ventilated and dried at 55°C, granulated through a 20-mesh sieve and mixed evenly with magnesium stearate to obtain granules 2 for later use.

[0092] The granule 1 and the ...

Embodiment 3

[0097]

[0098]

[0099] Preparation:

[0100] After the prescribed amount of fasudil and sildenafil were crushed through a 100-mesh sieve, they were mixed with lactose, low-substituted hydroxypropyl cellulose, starch and 60-mesh sieved sodium lauryl sulfate, Magnesium stearate is evenly mixed, and 3# capsules are filled to obtain compound capsules.

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PUM

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Abstract

The invention relates to a pharmaceutical composition containing fasudil and sildenafil for treating pulmonary hypertension, and a preparation method thereof, belonging to the field of pharmacy. The composition provided by the invention uses fasudil and sildenafil as the pharmaceutical active components, and the composition also comprises other pharmaceutically acceptable carriers, such as a disintegrant, an adhesive, an excipient, a thinner, a lubricant, a skeletal material for controlling the release rate of the active components in a sustained or controlled release preparation, and the like, and the suitable carriers are selected for different dosage forms.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing fasudil and sildenafil and a preparation method thereof, which are used for the treatment of pulmonary hypertension and belong to the field of pharmacy. Background technique [0002] Fasudil [hexahydro-1-(5-isoquinolinesulfonyl)-homopiperazine, Fasudil] is a Rho kinase inhibitor. Its molecular weight is 327.83 and its molecular formula is C 14 h 17 N 30 2S·HCl, structural formula: [0003] [0004] Studies have confirmed that the Rho kinase pathway is one of the important pathogenic pathways leading to pulmonary artery constriction and pulmonary vascular remodeling in patients with pulmonary arterial hypertension. For pulmonary hypertension, fasudil can reduce the activity of Rho kinase, inhibit the contraction of pulmonary artery vascular smooth muscle, dilate pulmonary arteries, reduce pulmonary artery resistance, and reduce pulmonary arterial pressure. [0005] Sildenafil is a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/551A61K31/519A61P11/00A61P9/12
Inventor 姚小青孙长海董凯韩志东
Owner TIANJIN CHASE SUN PHARM CO LTD
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