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Pharmaceutical composition for treating Alzheimer disease symptom and its preparation method

A dementia and composition technology, applied in the field of traditional Chinese medicine, can solve the problems of large side effects, failure to curb the disease, and high treatment costs, and achieve the effects of improving memory, increasing the number of cell synapses, and improving microcirculation

Inactive Publication Date: 2011-09-21
CHANGCHUN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are great deficiencies in these western medicine treatments: 1. The cost of treatment is too high
2. It can only relieve the symptoms, but cannot curb the further development of the disease
3. Large side effects
There are no reports at home and abroad that traditional Chinese medicine with ginseng leaves as a prescription has a significant effect on senile dementia

Method used

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  • Pharmaceutical composition for treating Alzheimer disease symptom and its preparation method
  • Pharmaceutical composition for treating Alzheimer disease symptom and its preparation method
  • Pharmaceutical composition for treating Alzheimer disease symptom and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 granule preparation

[0026] Epimedium 400g, ginseng leaves 200g, ginkgo leaves 200g;

[0027] Take epimedium, ginseng leaves, and ginkgo leaves in the formula and add 7 times the amount of 60% ethanol to reflux and extract twice, each time for 1.5h, filter, combine the filtrates, recover ethanol, concentrate to 80 °C and measure the relative density of 1.1. Paste, put on the macroporous resin D101 column that has been treated, elute with water and 20% ethanol, discard, and finally elute with 50% ethanol, collect, recover ethanol, and measure the extract with a relative density of 1.1 when concentrated to 80°C. Add appropriate amount of sucrose powder and dextrin, mix well, granulate with ethanol of appropriate concentration, dry, granulate, and pack separately to obtain.

Embodiment 2

[0028] Embodiment 2 capsule preparation

[0029] Epimedium 300g, ginseng leaves 300g, ginkgo leaves 300g;

[0030] Take epimedium, ginseng leaves, and ginkgo leaves in the formula and add 8 times the amount of 70% ethanol to reflux and extract twice, each time for 1.5h, filter, combine the filtrates, recover ethanol, concentrate to 80 °C and measure the relative density of 1.2. Paste, put on the macroporous resin D101 column that has been treated, elute with water and 20% ethanol, discard, and finally elute with 60% ethanol, collect, recover ethanol, measure the extract with a relative density of 1.2 when concentrated to 80°C, Dried, crushed into fine powder, granulated with ethanol of appropriate concentration, dried, granulated, and packed into capsules.

Embodiment 3

[0031] Embodiment 3 water pill preparation

[0032] Epimedium 200 parts, ginseng leaves 400 parts, ginkgo leaves 400 parts.

[0033] Take epimedium, ginseng leaves, and ginkgo leaves in the formula and add 9 times the amount of 80% ethanol to reflux and extract for 3 times, each time for 1.5h, filter, combine the filtrates, recover ethanol, and concentrate it into an infusion with a relative density of 1.3 at 80°C. Paste, put on the macroporous resin D103 column that has been treated, elute with water and 20% ethanol, discard, and finally elute with 70% ethanol, collect, recover ethanol, measure the extract with a relative density of 1.3 when concentrated to 80°C, Dried, crushed into fine powder, and made into pills with water or starch slurry of appropriate concentration. Drying, polishing, packaging, that is.

[0034] The beneficial effects of the medicament of the present invention are further described below through test examples, and these test examples include the phar...

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Abstract

The invention relates to a pharmaceutical composition for treating Alzheimer disease symptom and its preparation method, which belongs to the technical field of traditional Chinese medicines. The pharmaceutical composition provided in the invention is prepared by bulk drugs of the following proportions by weight: 200 to 400 portions of epimeddium, 200 to 400 portions of ginseng leaf, 200 to 400 portions of ginkgo biloba. The pharmaceutical composition provided in the invention has the effects for warming kidney-yang, invigorating spleen and replenishing qi, activating blood and dissolving stasis. The present invention is used for treating Alzheimer disease and yang deficiency of spleen and kidney. The main syndromes comprise that: hypophrenia, indifferent look, tiredness and sleepy feel. The secondary syndromes comprise that: dull expression, bradyphnisia, soreness and weakness of waist and knees, lack of appetite and anorexia, walking with heavy steps, sialorrhea, pale tongue, thin coating deep thready pulse.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, in particular for treating senile dementia. Background technique [0002] Alzheimer's disease (Alzheimer's disease, AD) is dementia caused by chronic progressive central nervous system degenerative disease, characterized by neuropsychiatric symptoms such as progressive memory impairment, cognitive dysfunction, personality changes, and language barriers. feature. Clinical epidemiological studies show that AD accounts for about 70% of senile dementia. At present, the number of AD patients in the world is estimated to be around 20-25 million. Some experts predict that Alzheimer's disease will become the number one killer of human beings in the 21st century. [0003] The pathogenesis of senile dementia is complicated, and there is no specific drug for treatment at present, and it is impossible to make a breakthrough in the prevention and treatment in the near future. Therefore...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/296A61P25/28
Inventor 张永和陈心智王明星于秀华欧喜燕柳静初洪波周鸣王丽娟李弛坤李晓兵
Owner CHANGCHUN UNIV OF CHINESE MEDICINE
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