Application of taurochenodeoxycholic acid in protection of adrenal gland function

A technology of taurochenodeoxycholic acid and adrenal glands, which is applied to medical preparations containing active ingredients, endocrine system diseases, organic active ingredients, etc., and can solve problems such as undiscovered application of taurochenodeoxycholic acid

Inactive Publication Date: 2011-09-14
SHANDONG AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of exogenous substances to affect the secretion of adrenaline is now a common treatment method, but the application of taurochenodeoxycholic acid in this field has not been found

Method used

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  • Application of taurochenodeoxycholic acid in protection of adrenal gland function
  • Application of taurochenodeoxycholic acid in protection of adrenal gland function
  • Application of taurochenodeoxycholic acid in protection of adrenal gland function

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Experimental program
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Effect test

Embodiment 1

[0022] During the experiment, they were divided into normal group, model group and drug administration group, each with 10 mice. The normal group was only fed with distilled water; the model group was injected intraperitoneally with 80 mg / kg dexamethasone for 7 consecutive days to prepare the mouse model of adrenal suppression caused by glucocorticoids; the administration group was prepared in the model After completion of the administration, the dose of TCDCA in the administration group was 0.1 g / kg, and the route of administration was intragastric administration, once a day, for 7 consecutive days. The mice were dissected in the normal group, the model group and the middle-dose administration group, especially the adrenal gland was observed, and the results of the anatomical changes of the adrenal gland were found in the attached figure 1 And attached Figure 5 shown. It can be seen that, compared with the administration group, the model group has symptoms of congestion an...

Embodiment 2

[0024] During the experiment, they were divided into normal group, model group and drug administration group, each with 10 mice. The normal group was only fed with distilled water; the model group was injected intraperitoneally with 80 mg / kg dexamethasone for 7 consecutive days to prepare the mouse model of adrenal suppression caused by glucocorticoids; the administration group was prepared in the model After completion of the administration, the dose of TCDCA in the administration group was 0.1 g / kg, and the route of administration was intragastric administration, once a day, for 7 consecutive days. HE staining of paraffin sections was used to evaluate the influence of TCDCA on the pathological changes of the adrenal gland, and the results are shown in the appendix figure 2 And attached Figure 6 shown. In the model group, the epithelial cells of the adrenal ducts had granular degeneration, decreased in number, and congestion of small blood vessels in the interstitium of t...

Embodiment 3

[0026] During the experiment, they were divided into normal group, model group and drug administration group, each with 10 mice. The normal group was only fed with distilled water; the model group was injected intraperitoneally with 80 mg / kg dexamethasone for 7 consecutive days to prepare the mouse model of adrenal suppression caused by glucocorticoids; the administration group was prepared in the model After completion of the administration, the dose of TCDCA in the administration group was 0.1 g / kg, and the route of administration was intragastric administration, once a day, for 7 consecutive days. TUNEL method was used to detect the effect of TCDCA on the apoptosis of adrenal gland cells. The tissue sections were observed and photographed under a 400-fold optical microscope. Dark brown cells were apoptotic cells, and light blue cells were normal cells. Three consecutive fields of view were selected in the adrenal cortex fascicularis, and the number of stained cells and the...

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Abstract

The invention relates to new application of taurochenodeoxycholic acid, in particular to new application of taurochenodeoxycholic acid in the protection of an adrenal gland function. By the study of the taurochenodeoxycholic acid, the inventor discovers that the taurochenodeoxycholic acid can resist the apoptosis of adrenal glands and promote the multiplication of adrenal cortex stem cells, so the taurochenodeoxycholic acid is applied to the protection of the adrenal gland function; and the taurochenodeoxycholic acid can be administrated directly, and also can be prepared in various formulations for resisting a stress reaction or preventing and treating other diseases or states related to adrenal gland hypofunction.

Description

technical field [0001] The invention relates to a new application of taurochenodeoxycholic acid, in particular to a new application of taurochenodeoxycholic acid in protecting adrenal function. Background technique [0002] Taurochenodeoxycholic Acid (TCDCA) is a conjugated bile acid mainly present in the bile of chickens, ducks, geese, cattle, sheep, snakes and other animals. Its chemical name is 3α, 7α-dihydroxy-5β-24-cholanoyl-N-taurine, and its structural formula is as follows: [0003] [0004] It is an odorless, white powder, extremely bitter acidic compound formed by combining taurine (Tau) and chenodeoxycholic acid (CDCA). The molecular formula is C 23 (OH) 2 h 37 CONHCH 2 CH 2 SO 3 H, the relative molecular mass is 499.69. As a main component of bile, TCDCA has the characteristics of wide range of drug sources, safety and efficacy. Current studies have found that TCDCA has anti-inflammatory (Li Peifeng, Cao Jinshan, Guan Hong, etc. Journal of Chinese Vete...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61P5/38
Inventor 石有斐李金莲王丛丛夏俊峰李培锋
Owner SHANDONG AGRICULTURAL UNIVERSITY
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