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Biological activity detection-based evaluation method of quality of prepared radix rehmanniae

A technology for quality evaluation and biological activity, applied in the field of medicine

Inactive Publication Date: 2011-09-07
HENAN UNIV OF CHINESE MEDICINE
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Problems solved by technology

[0005] In view of the above situation, in order to overcome the defects of the prior art, the object of the present invention is to provide a method for evaluating the quality of rehmannia glutinosa based on biological activity detection, which can effectively solve the problem of evaluating the quality of rehmannia glutinosa from multiple perspectives, and then ensure the medicinal quality of rehmannia glutinosa. The problem

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  • Biological activity detection-based evaluation method of quality of prepared radix rehmanniae

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[0011] The specific implementation of the present invention will be described in detail below in combination with specific situations.

[0012] First of all, it should be pointed out that Rehmannia glutinosa has the functions of anti-oxidation and scavenging free radicals. It is one of the most commonly used traditional Chinese medicines in clinical practice. One of the mechanisms of action. Studies have shown that different extracts of Rehmannia glutinosa have significant anti-oxidation and scavenging effects on peroxygen free radicals in vivo and in vitro.

[0013] Diphenylpicryl phthalein free radical (DPPH * ) chemical structure: 1,1-diphenyl-2-trinitrophenylhydrazine (1,1-Diphenyl-2-picrylhydrazyl radical 2,2-Diphenyl-1-(2,4,6-trinitrophenyl)hydrazyl) Molecular formula: C 18 h 12 N 5 o 6 It is a free radical with a single electron and has a strong absorption at 517nm, and its alcohol solution is purple. When there is an anti-oxidant (free radical scavenging) compon...

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Abstract

The invention relates to a biological activity detection-based evaluation method of the quality of prepared radix rehmanniae, effectively solving the problems of evaluating the quality of the prepared radix rehmanniae from multiple angles and then ensuring the medicinal quality of the prepared radix rehmanniae. The evaluation method comprises the following process steps of: taking medicinal materials; pretreating the medicinal materials; preparing a tested substance; carrying out a free radical elimination reaction experiment; measuring free radical elimination rate; comparing the tested substance with a reference substance; calculating valence; carrying out methodology investigation; measuring the valence value of batched samples; and evaluating the quality. By means of the method, a medical effect-based biological test method of the quality of traditional Chinese medicines by taking the prepared radix rehmanniae as an object is established and is used as the supplement and the enhancement of the conventional and chemical measurement of a pharmacopeia, the inner quality can be checked on together from multiple angles, the traditional quality control and quality evaluation method and standard are perfected, and a new technical condition is provided for the quality control and the quality evaluation research of other traditional Chinese medicines with undefined medical effect substances.

Description

1. Technical field [0001] The invention relates to medicine, in particular to a method for evaluating the quality of Rehmannia glutinosa based on biological activity detection. 2. Background technology [0002] The current internal quality evaluation and quality control of traditional Chinese medicine adopt the mode of qualitative detection and / or content determination of some index components. Since most of the effective substances of traditional Chinese medicine are not clear at present, this mode is difficult to ensure the consistency and stability of the quality of this type of traditional Chinese medicine. It is also difficult to correlate or reflect the safety and efficacy of its clinical use. The 2010 edition of the "Chinese Pharmacopoeia" clearly pointed out that it is necessary to establish a quality standard system in line with the characteristics of traditional Chinese medicine, gradually transition from the qualitative and quantitative of a single index component...

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Application Information

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IPC IPC(8): G01N21/31
Inventor 李寒冰刁青蕊吴宿慧张宾方晓艳王灿栗俞程
Owner HENAN UNIV OF CHINESE MEDICINE
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