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Solid oseltamivir phosphate medicinal composition

A technology of oseltamivir phosphate and composition, which can be used in liquid delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve the problems of large dosage, inability to ensure the safety of administration, and incompatibility.

Active Publication Date: 2011-09-07
HAIKOU QILI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] It can be seen that because the dosage of capsules is too large, it is difficult to accurately administer medicines to children, especially young children, and the safety of administration cannot be ensured; Not suitable for these specific groups of people

Method used

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  • Solid oseltamivir phosphate medicinal composition
  • Solid oseltamivir phosphate medicinal composition
  • Solid oseltamivir phosphate medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Embodiment 1: Preparation of oseltamivir phosphate solid pharmaceutical composition

[0058] Element

[0059] Both oseltamivir phosphate and sodium glutamate were crushed through a 100-mesh sieve, and the prescribed amount of oseltamivir phosphate and sodium glutamate were accurately weighed, mixed evenly; divided into plastic bottles, each bottle containing oseltamivir phosphate Seltamivir 600mg, ready to use.

Embodiment 2

[0060] Embodiment 2: Preparation of oseltamivir phosphate solid pharmaceutical composition

[0061] Element

[0062] Both oseltamivir phosphate and sodium glutamate were crushed through a 100-mesh sieve, and the prescribed amount of oseltamivir phosphate and sodium glutamate were accurately weighed, mixed evenly; divided into plastic bottles, each bottle containing oseltamivir phosphate Seltamivir 600mg, ready to use.

Embodiment 3

[0063] Embodiment 3: Preparation of oseltamivir phosphate solid pharmaceutical composition

[0064] Element

[0065] Both oseltamivir phosphate and sodium glutamate were crushed through a 100-mesh sieve, and the prescribed amount of oseltamivir phosphate and sodium glutamate were accurately weighed, mixed evenly; divided into plastic bottles, each bottle containing oseltamivir phosphate Seltamivir 600mg, ready to use.

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Abstract

The invention provides a powdered oseltamivir phosphate medicinal composition, which comprises a therapeutic or prevention effective amount of oseltamivir phosphate, sodium glutamate and any one or more pharmaceutically acceptable excipients. The invention also provides the use of the solid medicinal composition in the preparation of oral liquid medicines and further provides a liquid medicinal composition which comprises the solid medicinal composition provided by the invention and a water-containing medium. When prepared into suspension with water, the solid medicinal composition has a stable advantage.

Description

technical field [0001] The present invention relates to a novel pharmaceutical composition of oseltamivir phosphate. Background technique [0002] Neuraminidase (NA) inhibitors are a class of anti-influenza virus drugs developed in recent years. As a newly developed neuraminidase inhibitor, oseltamivir phosphate is effective against both type A and type B influenza viruses, It is not easy to drug resistance, well tolerated by patients, and has high safety. It is clinically used for the prevention and treatment of influenza. [0003] Oseltamivir (Oseltamivir, used as its phosphate salt) is a therapeutic drug for the prevention and control of influenza pandemics by the World Health Organization and the Ministry of Health of my country, and it is also a national strategic reserve drug for the prevention and control of influenza pandemics in my country and other countries in the world. [0004] At present, in my country, the commercially available oseltamivir phosphate dosage f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/215A61K31/198A61K9/16A61K9/10A61P31/16
Inventor 李春娟
Owner HAIKOU QILI PHARMA
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