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Gastric stasis system of total alkaloids of coptis and evodia rutaecarpa as well as preparation method and application thereof

A technology of gastric retention and continuous dogwood, which is applied to the digestive system, pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve the problems of reducing the bioavailability of drugs, simple extraction and purification process, and long floatation time, etc. Significant gastric retention, stable preparation process and good reproducibility

Inactive Publication Date: 2011-08-17
SICHUAN ACAD OF CHINESE MEDICINE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The content of alkaloids extracted from these two articles is low, and because no foaming agent is used, the floating time of the preparation becomes longer (about 2 minutes), which obviously affects the floating performance of the preparation and reduces the bioavailability of the drug
[0010] In addition, Xia Yanjiao et al.'s "Research on the Preparation and In Vitro Release of Lianyu Total Alkaloids in the Gastric Release Tablets", the extraction and purification process is too simple in the text, and it is not very clear. The effective part may be prepared, but the types and proportions of excipients are not described. Only the drug release performance of the preparation has been studied, and the floating performance of the preparation has not been studied. The retention performance needs to be investigated
[0011] "Influence of Hydroxypropyl Methyl Cellulose on the Floatability and Drug Release Characteristics of Zuojinwei Floating Sustained Release Tablets" by Zhao Xinhui et al. and the gastric floating tablet prepared by Evodia rutaecarpa extract, but the method of extraction and purification and the content of active ingredients are not described in the text, and the preparation has a longer floating time, which will seriously affect the floating performance of the preparation (floating performance in the present invention) time less than 5 seconds), reducing the bioavailability of the drug
[0012] In addition, the above-mentioned patents and documents also have a common shortcoming. Judging from the experimental results given, it is impossible to realize the real gastric retention effect at all, let alone Propose an effective in vivo evaluation method for the prepared preparation and demonstrate its retention behavior in the gastrointestinal tract of animals or humans, the real effect needs to be further verified

Method used

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  • Gastric stasis system of total alkaloids of coptis and evodia rutaecarpa as well as preparation method and application thereof
  • Gastric stasis system of total alkaloids of coptis and evodia rutaecarpa as well as preparation method and application thereof
  • Gastric stasis system of total alkaloids of coptis and evodia rutaecarpa as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Extraction Technology of Total Alkaloids of Coptis Rhizoma

[0063] Take Coptis rhizome and crush it into coarse powder, use 1.0% hydrochloric acid aqueous solution as solvent, soak for 24 hours, then percolate, and collect 8 times the amount of filtrate. Use sodium hydroxide particles to adjust the pH value of the percolation liquid to 5, let stand overnight, filter, add 1mol / L dilute hydrochloric acid to the filtrate to adjust the pH value to 1-2, add sodium chloride to make the final concentration 10%, let stand overnight , filtered, and the precipitate was washed with water until the pH value was 5, dried under reduced pressure, and pulverized to obtain the obtained product.

Embodiment 2

[0065] Extraction Technology of Total Alkaloids from Evodia Evodia

[0066] Take the coarse powder of Evodia rutaecarpa, add 80% ethanol to reflux extraction for 3 times, each time for 1.5 hours, add 6 times of 80% ethanol for the first time, add 5 times of 80% ethanol for the second and third times, filter while it is hot, combine the ethanol liquid, reduce Concentrate under pressure, stir and add sodium hydroxide to make the concentration 1.5%, let it stand overnight, filter, wash the precipitate with water until it is neutral, and further refine it to obtain it.

Embodiment 3

[0068] The total alkaloids of Evodia rutaecarpa in Example 2 and the total alkaloids of Coptis chinensis in Example 1 were mixed at a weight ratio of 6:1 to obtain the total alkaloids of Evodia rutaecarpa used in the following examples.

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Abstract

The invention provides a gastric stasis system of total alkaloids of coptis and evodia rutaecarpa, which has favorable bioavailability and floating performance, as well as a preparation method and application thereof, in particular relates to an intragastric floating sheet and an intragastric adhering sheet. With a famous Chinese medicine prescription, i.e. golden cornus pills as a basis, effective part groups of total alkaloids of coptis and evodia rutaecarpa in medicine materials in the prescription are extracted and purified and mixed with appropriate floating material, adhering material, foaming material, framework material and lubricating agent to obtain a mixture, and the mixture is prepared into the intragastric floating sheet and the intragastric adhering sheet by using routine techniques in the field of pharmacy.

Description

technical field [0001] The invention relates to a gastric retention system of total alkaloids of lentils and its preparation method and application, more specifically, to an intragastric floating tablet and an intragastric adhesive tablet of total alkaloids of lentils, belonging to the field of traditional Chinese medicine preparations. Background technique [0002] The total alkaloids of Lianyu is the abbreviation of the total alkaloids of Coptis chinensis and the total alkaloids of Evodia rutaecarpa, which comes from the famous traditional Chinese medicine Fang Zuojin Wan. Zuojin Wan is composed of Coptis chinensis and Evodia rutaecarpa with a 6:1 formula. It comes from Zhu Zhenxiang's "Danxi Xinfa · Fire Six" in the Yuan Dynasty, and it is a prescription recorded in "Chinese Pharmacopoeia". Zuojin Wan clears liver and gallbladder fire and relieves spleen and stomach heat. It has the effect of harmonizing stomach and lowering adverse reactions, suppressing acid and relievi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/754A61K9/20A61K9/48A61K47/38A61P1/04A61P1/08A61P1/14
Inventor 徐超群赵军宁易进海袁志翔詹雁阮佳谭镭
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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