Gastric stasis system of total alkaloids of coptis and evodia rutaecarpa as well as preparation method and application thereof
A technology of gastric retention and continuous dogwood, which is applied to the digestive system, pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve the problems of reducing the bioavailability of drugs, simple extraction and purification process, and long floatation time, etc. Significant gastric retention, stable preparation process and good reproducibility
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Embodiment 1
[0062] Extraction Technology of Total Alkaloids of Coptis Rhizoma
[0063] Take Coptis rhizome and crush it into coarse powder, use 1.0% hydrochloric acid aqueous solution as solvent, soak for 24 hours, then percolate, and collect 8 times the amount of filtrate. Use sodium hydroxide particles to adjust the pH value of the percolation liquid to 5, let stand overnight, filter, add 1mol / L dilute hydrochloric acid to the filtrate to adjust the pH value to 1-2, add sodium chloride to make the final concentration 10%, let stand overnight , filtered, and the precipitate was washed with water until the pH value was 5, dried under reduced pressure, and pulverized to obtain the obtained product.
Embodiment 2
[0065] Extraction Technology of Total Alkaloids from Evodia Evodia
[0066] Take the coarse powder of Evodia rutaecarpa, add 80% ethanol to reflux extraction for 3 times, each time for 1.5 hours, add 6 times of 80% ethanol for the first time, add 5 times of 80% ethanol for the second and third times, filter while it is hot, combine the ethanol liquid, reduce Concentrate under pressure, stir and add sodium hydroxide to make the concentration 1.5%, let it stand overnight, filter, wash the precipitate with water until it is neutral, and further refine it to obtain it.
Embodiment 3
[0068] The total alkaloids of Evodia rutaecarpa in Example 2 and the total alkaloids of Coptis chinensis in Example 1 were mixed at a weight ratio of 6:1 to obtain the total alkaloids of Evodia rutaecarpa used in the following examples.
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