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Medicinal composition for treating cardiovascular diseases, and preparation and preparation method thereof

A composition and cardiovascular technology, which is applied in the direction of cardiovascular system diseases, drug combinations, bone diseases, etc., to achieve the effect of good safety, high content of active ingredients, and high bioavailability

Inactive Publication Date: 2011-08-10
TIANSHENG PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The operation itself can cause myocardial infarction, and the transplanted blood vessels can be embolized after the operation. Therefore, the adaptability of the operation is relatively strict, and the applicable population is limited. It is not suitable for most patients with coronary heart disease.

Method used

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  • Medicinal composition for treating cardiovascular diseases, and preparation and preparation method thereof
  • Medicinal composition for treating cardiovascular diseases, and preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Embodiment 1 A pharmaceutical composition for treating cardiovascular disease, characterized in that: it is prepared by the following steps:

[0086] (1) Take 742g of salvia miltiorrhiza, 85g of notoginseng and 184g of safflower, prepare salvia miltiorrhiza and / or safflower water extract, and prepare notoginseng alcohol extract;

[0087] (2) performing preliminary clarification on the extract obtained in step (1);

[0088] (3) The notoginseng alcohol extract treated in step (2) is subjected to macroporous resin adsorption treatment, and the salvia miltiorrhiza and / or safflower water extract is subjected to alcohol precipitation treatment;

[0089] (4) Concentrating the extracts treated in step (3) respectively and then fully mixing them to obtain the pharmaceutical composition for treating cardiovascular diseases.

Embodiment

[0090] Embodiment 2 A pharmaceutical composition for the treatment of cardiovascular disease, characterized in that: it is prepared by the following steps:

[0091] (1) Take 977g of salvia miltiorrhiza, 139g of notoginseng and 221g of safflower, prepare the water extract of salvia miltiorrhiza and / or safflower, and prepare the notoginseng alcohol extract with n-butanol;

[0092] (2) performing preliminary clarification on the extract obtained in step (1);

[0093] (3) The notoginseng alcohol extract treated in step (2) is subjected to macroporous resin adsorption treatment, and the salvia miltiorrhiza and / or safflower water extract is subjected to alcohol precipitation treatment;

[0094] (4) Concentrating the extracts treated in step (3) respectively and then fully mixing them to obtain the pharmaceutical composition for treating cardiovascular diseases.

[0095] Embodiment 3 A pharmaceutical composition for treating cardiovascular disease, characterized in that it comprises...

Embodiment 4

[0101] Embodiment 4 A pharmaceutical composition for treating cardiovascular disease, characterized in that it comprises the following steps:

[0102] (1) Take 800g of Salvia miltiorrhiza, 112g of notoginseng and 213g of safflower, prepare the water extract of salvia miltiorrhiza and / or safflower, use 12 times of the weight of notoginseng to reflux extract the notoginseng twice with 70% ethanol, each After 1 hour, the extracts were combined to obtain a notoginseng alcohol extract;

[0103] (2) Using chitosan clarifying agent to carry out preliminary clarification treatment on the extract obtained in step (1) to remove larger suspended particles in the extract;

[0104] (3) The notoginseng alcohol extract treated in step (2) is subjected to macroporous resin adsorption treatment, and ethanol is added to the salvia miltiorrhiza and / or safflower extract treated in step (2) to make the extract The alcohol content is 70%, refrigerated, let stand for 40 hours, filter, recover the e...

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Abstract

The invention discloses a medicinal composition for treating cardiovascular diseases, which is characterized by being prepared from the following steps of: (1) preparing root of red-rooted salvia and / or safflower water extract from 742 to 977 grams of root of red-rooted salvia and 184 to 221 grams of safflower, and preparing notoginseng root alcohol extract from 85 to 139 grams of notoginseng root; (2) clarifying the extract obtained in the step (1) primarily; (3) adsorbing the notoginseng root alcohol extract processed in the step (2) by macroporous resin, and performing alcohol precipitation on the root of red-rooted salvia and / or safflower water extract; and (4) concentrating the extract processed in the step (3), and mixing fully. The invention also discloses a preparation of the medicinal composition and a preparation method for a freeze-dried powder injection. The medicinal composition has light color, low impurity content, high content of active ingredients and high bioavailability and safety, is strict in a formula and distinct in chief medicines, deputy medicines, adjuvant medicines and envoy medicines, and can be absorbed by human bodies conveniently, and meet first-aid requirements of patients who suffer from angina.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cardiovascular diseases and a preparation thereof, in particular to a pharmaceutical composition for treating cardiovascular diseases using Chinese medicinal materials as raw materials, a preparation thereof, and a preparation method of the preparation. Background technique [0002] With the improvement of people's living standards, the aging of the world's population and the rejuvenation of the diseased population, the number of patients with cardiovascular and cerebrovascular diseases has increased year by year, and has become the second largest killer of human health. Angina pectoris is a clinical syndrome caused by temporary myocardial ischemia and hypoxia, with episodic chest tightness or chest discomfort as the main manifestation. Coronary heart disease angina pectoris refers to angina pectoris caused by myocardial ischemia and hypoxia due to coronary artery sclerosis or spasm, ac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P9/10A61P9/12A61P19/08
Inventor 刘群刘行鹏昝琼李达富
Owner TIANSHENG PHARMA GROUP
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