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Application of soft capsule capable of clearing heat and eliminating toxin in preparation of medicament for treating viral pneumonia

A viral pneumonia, heat-clearing and detoxifying technology, applied in the field of medicine, can solve the problems of drug resistance of toxic side effects, limited effect of vaccines, and inability of vaccines to treat viral infections, etc., and achieve the effect of reducing lung index

Active Publication Date: 2011-08-03
CSPC OUYI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Vaccines cannot treat viral infections that have already occurred, and due to the specificity of the vaccine, the effect of the vaccine is very limited
At present, the antiviral drugs used to treat viral pneumonia include amantadine, ribavirin, zanamivir, oseltamivir, etc., but most of them have serious side effects and drug resistance, and neurological symptoms appear in clinical application. Systemic, digestive system and hematopoietic system adverse reactions, limiting the clinical use of drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Preparation of Qingrejiedu Soft Capsules

[0017] 1. Prescription: gypsum 3350g, honeysuckle 670g, Scrophulariaceae 535g, rehmannia 400g,

[0018] Forsythia 335g, Gardenia 335g, Sweet Diding 335g, Scutellaria baicalensis 335g,

[0019] Gentian 335g, Banlangen 335g, Anemarrhena 270g, Ophiopogon japonicus 270g.

[0020] 2. Extraction of active ingredients: the above twelve flavors, except honeysuckle and scutellaria baicalensis, other ten flavors such as gypsum, soaked in water for 1 hour, decocted twice, the first time for 1 hour, after boiling, let it cool for a while, and then added honeysuckle and Scutellaria baicalensis for 40 minutes for the second time, filter, combine the filtrates, concentrate to a relative density of about 1.17 (80°C), add ethanol to make the alcohol content reach 70%, stir well, refrigerate for 48 hours, filter, and recover ethanol from the filtrate And concentrated to a relative density of about 1.05-1.47, that is.

[0021] 3. Pr...

Embodiment 2

[0026] Example 2: Pharmacodynamic test of Qingrejiedu soft capsule against H1N1 influenza virus pneumonia

[0027] 1. Experimental materials

[0028] Virus Influenza A (H1N1) virus. Before use, it is inoculated in the allantoic cavity of healthy fertilized chicken eggs and expanded in mice, and stored at -80°C for future use.

[0029] Animals BALB / c mice, 5-7 weeks old, male and female, weighing 12±1 g, SPF grade.

[0030] Drug Qingrejiedu soft capsules were prepared by Ouyi Pharmaceutical Co., Ltd. of CSPC.

[0031] 2. Experimental method

[0032] 2.1 Toxic effect of Qingrejiedu soft capsule on mice and selection of drug dose

[0033] The content of 1.2g / capsule Qingrejiedu soft capsule was prepared with double distilled water to make a drug solution with a concentration of 150 mg·mL-1, and it was given to mice by gavage for 5 consecutive days, once a day, 0.2 ml each time, and the setting was normal The control group was observed for 20 days. There was no obvious abnor...

Embodiment 3

[0043] Example 3: Pharmacodynamic test of Qingrejiedu Soft Capsules against Influenza A H2N2 influenza virus pneumonia

[0044] 1. Experimental materials

[0045] Influenza A H2N2 virus is inoculated in the allantoic cavity of healthy fertilized chicken eggs and amplified in mice before use, and stored at -80°C for later use. BALB / c mice, 5-7 weeks old, half male and half male, body weight 12±1 g, SPF grade. Qingrejiedu Soft Capsules were prepared by CSPC Ouyi Pharmaceutical Co., Ltd.

[0046] 2. Experimental method

[0047] 2.1 Toxic effect of Qingrejiedu soft capsule on mice

[0048] The content of 1.2g / capsule Qingrejiedu soft capsule was prepared with double distilled water to make a drug solution with a concentration of 150 mg·mL-1, and it was given to mice by gavage for 5 consecutive days, once a day, 0.2 ml each time, and the setting was normal The control group was observed for 20 days. There was no obvious abnormality and death in the mice, and there was no signi...

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PUM

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Abstract

The invention provides the application of a soft capsule capable of clearing heat and eliminating toxin in the preparation of a medicament for treating viral pneumonia, wherein the soft capsule capable of clearing heat and eliminating toxin comprises active components prepared from the following raw materials in parts by weight: 670 parts of gypsum, 134 parts of honeysuckle, 107 parts of figwort root, 80 parts of rehmannia root, 67 parts of forsythia, 67 parts of cape jasmine fruit, 67 parts of Chinese violet, 67 parts of baical skullcap root, 67 parts of Chinese gentian, 67 parts of indigowoad root, 54 parts of anemarrhena asphodeloides bunge and 54 parts of dwarf lilyturf tuber. Results of clinical tests of the soft capsule show that: when the soft capsule capable of clearing heat and eliminating toxin is adopted, pulmonary indexes can be reduced; and moreover, the soft capsule has an obvious inhibition effect on the mouse viral pneumonia caused by virus infection, and can be used for preparing the medicament for treating the viral pneumonia.

Description

field of invention [0001] The invention relates to a new application of Qingrejiedu soft capsule, in particular to the application of Qingrejiedu soft capsule in preparing medicine for treating viral pneumonia, and belongs to the technical field of medicine. Background technique [0002] Viral pneumonia is inflammation of the lungs caused by viral infection. Influenza virus is the most common virus causing pneumonia, others are parainfluenza virus, cytomegalovirus, adenovirus, rhinovirus, coronavirus and some enteroviruses, such as coxsackie virus, echovirus, etc. Pneumonia often results from respiratory syncytial virus infection. Viral pneumonia mostly occurs in winter and spring, and can be sporadic or outbreaks. About 8% of acquired pneumonia requiring hospitalization is viral pneumonia. Infants, young children, the elderly, pregnant women, and those with poor immunity are prone to the disease, and the condition is serious, even leading to death. [0003] The main ways...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61P11/00A61P31/14A61P31/16A61K33/06
Inventor 高志峰齐新英杨占秋周杰张文静董新明刘聪敏韩彩霞李艳平
Owner CSPC OUYI PHARM CO LTD
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