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Composition containing collagen peptide for improving skin care

A composition and technology of collagen peptides, applied in skin diseases, drug combinations, skin care preparations, etc., to achieve the effect of preventing skin aging and inhibiting photoaging

Active Publication Date: 2011-07-20
AMOREPACIFIC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high molecular weight of collagen, there are various problems in digestion and absorption of collagen, delivery of collagen to target organs such as skin, delivery of effective amount of collagen to target organs, biocompatibility of collagen, etc.

Method used

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  • Composition containing collagen peptide for improving skin care
  • Composition containing collagen peptide for improving skin care
  • Composition containing collagen peptide for improving skin care

Examples

Experimental program
Comparison scheme
Effect test

experiment Embodiment 1

[0026] Experimental Example 1: Determination of Collagen Generation Ability

[0027] The ability to produce type 1 procollagen was determined by fibroblasts, as shown in Table 1 below.

[0028] [Table 1]

[0029] group

deal with

control group

In the normal group, cells were treated with saline

Comparative example 1

Cells were treated with normal saline dissolved in normal collagen material

[0030] Comparative example 2

Cells were treated with saline solution containing collagen peptides (purchased from Jellice)

[0031] In order to compare the ability of procollagen production between each group, the fibroblasts were divided into 5×10 4 The density of cells / well was added to a 48-well plate and allowed to attach to each well. In this state, the collagens of Comparative Examples 1 and 2 were added to the cells at final concentrations of 0.1 ppm, 1 ppm and 10 ppm, respectively. A group not treated with any collagen...

experiment Embodiment 2

[0037] Experimental Example 2: Optimizing Experiments Utilizing the Design of Experiments Method

[0038] In order to optimize the procollagen production ability of the collagen peptide component identified in Experimental Example 1 and other candidate raw materials (elastin, hyaluronic acid, and vitamin C), response surface methodology (RSM) was used. When using the response surface method, it can determine at what value the independent variable can be optimized, and can calculate the functional relationship between the independent variable and the dependent variable based on the data, thereby predicting the impact of the independent variable on the response variable (response variables) . Thus, optimal experimental conditions among the variables can be found. In the present invention, the central composite design method as a response surface method was performed using MiniTab 14, and the results are shown in Table 3 below.

[0039] [table 3]

[0040] The design and its me...

experiment Embodiment 3

[0049] Experimental Example 3: Photoaging Inhibition Experiment Using Skin Replicas

[0050] In order to examine the inhibitory effect of the composition of the present invention on photoaging, experiments were carried out using hairless mice as animal models. Female hairless mice (SKH, HR-1) aged 6-7 weeks were divided into three groups as shown in Table 5 below. Comparative Example 3 (normal group), Comparative Example 4 (UV control group), and Example 1, each group has 8 mice. These mice were bred during the experiment.

[0051] [table 5]

[0052]

[0053] In Comparative Examples 3 and 4, mice were orally administered 0.5 ml of normal saline, and in Example 1, the raw materials were mixed in an optimal ratio, and the mixture was added to 0.5 ml of in normal saline and administered orally to mice using a syringe. Here, the mixture contained 666 mg / kg collagen peptides, 13 mg / kg elastin and 1 mg / kg vitamin C and hyaluronic acid. The mixture was administered at the sam...

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Abstract

The present invention relates to an oral composition for improving skin care, which has the effects of smoothing skin and preventing wrinkles when taking the composition. More specifically, the composition of the present invention further contains one or more components selected from a group comprising elastin proteins, hyaluronic acid, and vitamin C in a collagen peptide. Especially, according to the present invention, the composition containing the collagen peptide, elastin protein, hyaluronic acid and vitamin C together in an optimized ratio does not cause side effects in the human body when taken. In addition, collagen biosynthesis of skin dermis is maximally promoted and the remaining rate in the user's body is very high. Also, the composition has the effects of suppressing wrinkles in the skin, maintaining or improving skin elasticity, and relieving dryness so it is useful as a healthy functional food for improving skin care and preventing skin aging.

Description

technical field [0001] The present invention relates to a skin cosmetic composition containing a collagen peptide mixture, more specifically, to a composition containing a collagen peptide and at least one selected from the group consisting of hyaluronic acid, elastin and vitamin C, and therefore A composition for skin beauty having an excellent effect of improving skin condition. Background technique [0002] Skin aging can be divided into intrinsic aging and extrinsic aging according to its causes. Intrinsic aging is a process in which skin structure and physiological functions decrease as a person ages, independent of environmental changes. Extrinsic aging is caused by continuous exposure to external environments such as sunlight. In particular, skin aging caused by light is called photoaging. UV light is a major factor in the physiological and morphological changes of skin aging. As intrinsic skin aging progresses, the skin becomes drier while fine lines increase and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64
CPCA61K8/65A61Q19/00A61K8/676A61K8/64A61K8/365A61K8/735A61Q19/08A61P17/16A61P17/18A61P43/00A61K8/73
Inventor 金正基李知海梁美淑李智恩金完起
Owner AMOREPACIFIC CORP
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