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Transdermal therapeutic preparation

A patch and hygroscopic technology, which is applied in the field of percutaneous absorption preparations, can solve the problems of not being able to inhibit yellowing and improve the stability of ketotifen content, so as to improve transdermal absorption and content stability, and inhibit yellowing Effect

Inactive Publication Date: 2012-11-14
SENJU PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But for the patch that contains ketotifen fumarate as an active ingredient, even if such packaging material is used for packaging, the content stability of ketotifen cannot be improved, and yellowing cannot be inhibited

Method used

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  • Transdermal therapeutic preparation
  • Transdermal therapeutic preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Among the components shown in Table 1, SIS-based adhesive base: Quintuck 3570C (manufactured by Nippon Zeon Co., Ltd.), rosin ester-based tackifier resin: Pink Crystal KE311 (manufactured by Arakawa Chemical Industry Co., Ltd.) and iso-palmitic acid The propyl ester was dissolved in toluene, and ketotifen fumarate and Tris were added to the solution to obtain an adhesive. This adhesive was coated on a silicon-treated PET film having a thickness of 75 μm so that the thickness after drying was 40 μm, and dried at 110° C. for 3 minutes to form an adhesive layer. Next, a PET film with a thickness of 25 μm was laminated on the adhesive layer. The patch obtained in this way was packaged in a hygroscopic packaging material (Toyaldray (trade name), manufactured by Toyo Arminium Co., Ltd.) to obtain the percutaneous absorption preparation of the present invention.

Embodiment 2

[0056] The percutaneous absorption preparation of the present invention was obtained in the same manner as in Example 1, except that the atmosphere in the packaging material was replaced with nitrogen (substitution rate of 70% or more).

Embodiment 3

[0058] Except that a 10% propyl gallate solution (methanol / toluene=1 / 9) was further added to the adhesive, the same procedure as in Example 1 was carried out to obtain the percutaneous absorption preparation of the present invention.

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Abstract

The invention provides an application of tri(hydroxymethyl) methyl amine and a moisture absorbing packing material. In a patch of ketotifen fumarate provided with an adhering agent layer on a supporting body, the tri(hydroxymethyl) methyl amine and the moisture absorbing packing material are used for improving the content stability of the ketotifen fumarate and inhibiting the xanthochromia.

Description

[0001] This application is a divisional application of a Chinese patent application with an application date of April 20, 2005, an application number of 200580049505.6, and an invention title of "percutaneous absorption preparation". technical field [0002] The invention relates to a transdermal absorption preparation, which contains Ketotifen fumarate as an active ingredient. The active ingredient has good transdermal absorption, the drug content in the preparation is stable over time, and yellowing can be suppressed. In further detail, the present invention relates to a transdermal absorption preparation in a patch formed by providing an adhesive layer on a support, and the adhesive layer contains fumaric acid In addition to ketotifen, a specific alkaline substance is contained, and the patch is packaged in a hygroscopic packaging material. Background technique [0003] 4-(1-methyl-4-piperidinylene)-4H-benzo[4,5]cycloheptane[1,2-b]thiophene-10(9H)-one (hereinafter referre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/18A61K47/14A61K47/32A61K47/44A61K31/4535A61K9/70A61P37/08A61P11/06A61P11/02A61P17/00A61P17/04A61P27/02
Inventor 川原康慈新籾康彦岛田纪子大鸟聪礒胁明治
Owner SENJU PHARMA CO LTD
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