Polyamine enhanced formulations for triptan compound iontophoresis

Abstract

A patch and compositions for iontophoresis of triptan compounds are described.

Description

technical field [0001] This application claims priority to US Application Serial No. 12 / 214,555, filed June 19, 2008, which is hereby incorporated by reference in its entirety. Background technique [0002] The method of iontophoresis was described by LeDuc in 1908 and has thus found commercial use in the delivery of ionically charged therapeutic molecules such as pilocarpine, lidocaine and dexamethasone. In this delivery method, positively charged ions are driven through the skin at the anode of the electrolytic system while negatively charged ions are driven through the skin at the cathode of the electrolysis system. [0003] Early, and current, devices for iontophoresis typically consist of two electrodes affixed to the patient by an adhesive material, each connected by wires to a remote power source, usually a microprocessor-controlled electrical instrument. [0004] A recent publication showed that sumatriptan can be efficiently transported transdermally using iontopho...

AI Technical Summary

Problems solved by technology

A notable limitation of the device is the two-component construction of the delivery system; the wire connection between the controller and the patch is cumbersome to the wearer

Furthermore, programmable controllers can be expensive if exploited on a single-use basis, or, if exploited on a repeated-use basis, programmable controllers can be lost, contaminated, damaged, etc.

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