Fructus evodiae and coptis chinensis hydrogel bapu paste preparation process and substrate

Abstract

The invention discloses a fructus evodiae and coptis chinensis hydrogel bapu paste as well as a preparation method and a substrate prescription thereof. The bapu paste is prepared from an extracted obtained by extracting and refining fructus evodiae, coptis chinensis and elecampane and a proper substrate and is used for treating digestive system diseases, such as gastral cavity and hypochondrium pain, belching acid regurgitation, heat defecation, gastric ulcer, and the like. The fructus evodiae and coptis chinensis hydrogel bapu paste is changed from a fructus evodiae and coptis chinensis tablet into a bapu dosage, has no acrimony or irritability, and is an external preparation for treating digestive diseases by transdermal medicament delivery. The preparation method comprises the following steps of: extracting volatile oil from fructus evodiae and elecampane by using a steam distilling method; refluxing medicament residues retained after volatile oil is extracted for three times with 5 times of 80 percent of ethanol; recycling the ethanol from extract liquid into an extract with the relative density of 1.15 to 1.40 for standby; refluxing a coptis chinensis drinking tablet for three times with 5 times of 70 percent of ethanol; recycling the ethanol till the relative density is 1.15 to 1.40; adding boil water with equal amount with medicaments, stirring, filtering during heat and adding 10 percent of hydrochloric acid into filter liquid for adjusting pH value to 1.6 to 2.0; pumping and filtering; washing the extract to neutrality with a small amount of cold distilled water; combining a coptis chinensis extract with the fructus evodiae and elecampane extract; concentrating to an extract with the relative density of 1.15 to 1.40 and adding the substrate to obtain the fructus evodiae and coptis chinensis bapu paste.

Description

technical field [0001] The invention relates to a transdermal external dosage form for treating stomach and hypochondriac pain, belching and acid regurgitation, hot stool, gastric ulcer and other digestive system diseases-a cataplasm modified from Yulian tablets. The invention particularly relates to the preparation process and matrix formulation of the medicine. Background technique [0002] The traditional Chinese medicine prescription of the present invention is derived from the Yulian tablet in the fifth volume of the standard issued by the Ministry of Traditional Chinese Medicine, and the original dosage form is a tablet. Yulian tablets are mainly used to treat digestive tract diseases clinically, mostly for gastric ulcer disease. According to the theory of "internal disease and external treatment" in traditional Chinese medicine, the present invention changes Yulian tablet into cataplasm, and treats the disease of "epigastric pain" in traditional Chinese medicine by t...

AI Technical Summary

Problems solved by technology

At the same time, traditional Chinese medicine cataplasms generally have the disadvantages of insufficient viscosity, poor stability, and long production cycle. Therefore, the present invention provides a kind of "internal disease external treatment" plaster variety that can be administered locally and act on the whole body.

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