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Methods for preparing 3-cyclopentamine and slats thereof

A technology of cyclopentenylamine salt and cyclopentenylamine, which is applied in the field of compound preparation, can solve the problems of unobtainable starting materials, long synthesis route, high price and the like, and achieves avoiding diazotization reaction, short synthesis route, Easy to use effect

Inactive Publication Date: 2013-07-24
苏州莱克施德药业有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Because the synthetic route is relatively long, the yield is low, the starting materials are not easy to obtain and the price is expensive, resulting in a high cost of preparing the compound

Method used

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  • Methods for preparing 3-cyclopentamine and slats thereof
  • Methods for preparing 3-cyclopentamine and slats thereof

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Abstract

The invention discloses methods for preparing 3-cyclopentamine and slats thereof. The method for preparing the 3-cyclopentamine comprises the following steps of: adding cis-1,4-dichloro-2-butene and nitromethane serving as initial raw materials into a solvent to perform a reaction in the presence of an alkaline catalyst and at the temperature of 25 to 80 DEG C to obtain 4-nitro-cyclopentyl-1-alkenyl; and reducing the 4-nitro-cyclopentyl-1-alkenyl in a reduction system to obtain the 3-cyclopentamine. The new process provided by the invention reduces the course for synthesizing the target product to a relatively large extent, successfully solves the problems of high-price, rareness and the like of the raw materials of the target product and avoids a diazotization reaction at the same time. The new process greatly reduces production cost, improves yield and product purity and is simple in operation and convenient for mass production.

Description

Technical field [0001] The present invention involves a preparation method of a compound, especially the preparation method of 3-cycloidine and its salt. Background technique [0002] Due to the particularity of compounds 3-cycloidine structure, it is widely used as intermediates for pharmaceutical chemicals and fine chemicals. In conventional, the preparation of this compound is 3-cyclopenne -1-alcohol as the raw material, which is protected by methionic acid, nitrogen sodium is nitride, and then 3-cycloidine is obtained by hydrolysis. The response route is: Because the synthetic route is relatively long and the income is low, the starting raw materials are not easy to obtain and the price is expensive, resulting in a high cost of preparing the compound. Invention content One of the technical issues to be solved by the present invention is to provide 3-cyclopennenate preparation methods, with short synthetic routes and low preparation costs. The two technical problems to b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C211/40C07C209/34C07C209/68
Inventor 孙光明
Owner 苏州莱克施德药业有限公司
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