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Methods for preparing 3-cyclopentamine and slats thereof

A technology of cyclopentenylamine salt and cyclopentenylamine, which is applied in the field of compound preparation, can solve the problems of unavailable starting materials, long synthetic route, and high price, and achieve avoidance of diazotization reaction, short synthetic route, The effect of easy operation

Inactive Publication Date: 2011-04-27
苏州莱克施德药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Because the synthetic route is relatively long, the yield is low, the starting materials are not easy to obtain and the price is expensive, resulting in a high cost of preparing the compound

Method used

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  • Methods for preparing 3-cyclopentamine and slats thereof
  • Methods for preparing 3-cyclopentamine and slats thereof

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Abstract

The invention discloses methods for preparing 3-cyclopentamine and slats thereof. The method for preparing the 3-cyclopentamine comprises the following steps of: adding cis-1,4-dichloro-2-butene and nitromethane serving as initial raw materials into a solvent to perform a reaction in the presence of an alkaline catalyst and at the temperature of 25 to 80 DEG C to obtain 4-nitro-cyclopentyl-1-alkenyl; and reducing the 4-nitro-cyclopentyl-1-alkenyl in a reduction system to obtain the 3-cyclopentamine. The new process provided by the invention reduces the course for synthesizing the target product to a relatively large extent, successfully solves the problems of high-price, rareness and the like of the raw materials of the target product and avoids a diazotization reaction at the same time. The new process greatly reduces production cost, improves yield and product purity and is simple in operation and convenient for mass production.

Description

technical field [0001] The invention relates to a preparation method of a compound, in particular to a preparation method of 3-cyclopentenylamine and a salt thereof. Background technique [0002] Due to the special structure of the compound 3-cyclopentenylamine, it is widely used as an intermediate in pharmaceutical chemical industry and fine chemical industry. Conventionally, the preparation of this compound uses 3-cyclopenten-1-ol as a raw material, which is protected by methanesulfonic acid, diazotized by sodium azide, and then hydrolyzed to obtain 3-cyclopentenenamine. The reaction route is: Because the synthetic route is relatively long, the yield is low, and the starting materials are difficult to obtain and expensive, resulting in high cost of preparing the compound. Contents of the invention One of the technical problems to be solved by the present invention provides the preparation method of 3-cyclopentenylamine, the synthetic route is short, and the prepar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C211/40C07C209/34C07C209/68
Inventor 孙光明
Owner 苏州莱克施德药业有限公司
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