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Drug for treating coronary heart disease and preparation method thereof

A coronary heart disease and drug technology, applied in the field of drugs for the treatment of coronary heart disease, can solve the problems of slow absorption, inability to meet the emergency needs of patients with angina pectoris, and low bioavailability

Active Publication Date: 2011-04-27
TIANJIN TASLY MORDEN TCM RESOURCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are ordinary compound Danshen tablets and capsules on the market, but the production technology of ordinary tablets and capsules is backward, the content of active ingredients is low, and there is no quality control index. It needs to be taken orally and absorbed through the gastrointestinal tract, and absorbed after the first-pass effect in the liver. Into the blood, low bioavailability, slow absorption. It is not suitable for the first aid needs of patients with angina pectoris

Method used

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  • Drug for treating coronary heart disease and preparation method thereof
  • Drug for treating coronary heart disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Embodiment 1 The preparation of the drug drop pill for the treatment of coronary heart disease, each component is made up of the weight percent of active ingredient of medicine in terms of crude drug: Salvia miltiorrhiza 82.87%, Radix Notoginseng 16.21%, Borneol 0.92%;

[0070] Step 1: Extract 3 times the amount of Danshen with 95% ethanol under reflux for 2 hours, filter; add 2 times the amount of 95% ethanol to the dregs, extract under reflux for 1 hour, filter, concentrate the extract under reduced pressure, and dry to obtain 95% alcohol extraction of Salvia miltiorrhiza thing;

[0071] Step 2, take the dregs of Danshen 95% alcohol extraction in step 1, add 5 times the amount of 40% ethanol to reflux for extraction for 1.5hr, filter, add 4 times the amount of 50% ethanol to the remaining dregs, add 4 times the amount of 50% ethanol to extract for 1hr, filter, and concentrate the filtrate to nothing Alcohol, let cool to below 10°C, add dilute hydrochloric acid until t...

Embodiment 2

[0074] Embodiment 2 The preparation of the medicine dripping pill for the treatment of coronary heart disease, each component is made up of the weight percentage of active ingredient of medicine in terms of crude drug: Salvia miltiorrhiza 19.8%, Radix Notoginseng 78.2%, Borneol 2%;

[0075] Step 1, 85% ethanol with 2 times the amount of Danshen, reflux extraction once, 1 hour each time, filter, concentrate the extract under reduced pressure, and dry to obtain 85% ethanol extract of Danshen;

[0076] Step 2, take the dregs of step 1 alcohol extraction, add 3 times the amount of 20% ethanol for reflux extraction for 1 hr, filter, add 4 times the amount of 50% ethanol for reflux extraction of the dregs for 1 hr, filter, concentrate the filtrate to no alcohol, let cool to 10 Below ℃, add dilute hydrochloric acid to the pH value of 1.8-2.0, refrigerate and stand for more than 12 hours, filter the pulp plate, apply AB-8 macroporous resin, wash with water first, discard the eluent; th...

Embodiment 3

[0079] The preparation of the medicine of embodiment 3 treatment coronary heart disease, each component is made up of the weight percent of active ingredient of medicine based on crude drug: Salvia miltiorrhiza 97%, Panax notoginseng 2%, Borneolum 1%,

[0080] Step 1, 5 times the amount of Danshen root in 95% ethanol, reflux extraction 3 times, each time for 3 hours, filter, the extract was concentrated under reduced pressure and dried to obtain 95% alcohol extract of Danshen;

[0081] Step 2, take the dregs of step 1 alcohol extraction, add 8 times the amount of 60% ethanol to reflux for extraction for 4 hours, filter, add 4 times the amount of 50% ethanol to the dregs and extract for 1 hr, filter, concentrate the filtrate to no alcohol, let it cool to 10 Below ℃, add dilute hydrochloric acid to the pH value of 1.8-2.0, refrigerate and stand for more than 12 hours, Filter, apply AB-8 macroporous resin, wash with water first, discard the eluent; then wash with 15% ethanol, di...

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Abstract

The invention relates to a drug for treating coronary heart disease and a preparation method thereof. The preparation method comprises the following steps: extracting salvia with alcohol, extracting notoginseng with water and the like. The invention has the following advantages: the process route can realize industrialization and the quality is stable and controllable. Relevant experiments show that the drug has high curative effect and product purity, good absorbability, stable quality and novel application compared with the prior art, and meanwhile, the preparation method is simple in process, convenient to operate, low in cost and suitable for industrial production.

Description

technical field [0001] The invention relates to a medicine for treating coronary heart disease, which belongs to the field of traditional Chinese medicine. Background technique [0002] With the improvement of living standards, the aging of the world's population and the rejuvenation of the disease population, cardiovascular and cerebrovascular patients are increasing year by year, and have become the second largest disease that endangers human health. Angina pectoris is a clinical syndrome caused by temporary myocardial ischemia and hypoxia, with episodic chest pain or chest discomfort as the main manifestation. Coronary heart disease angina pectoris refers to angina pectoris caused by myocardial ischemia and hypoxia due to coronary artery sclerosis or spasm, accounting for about 90% of angina pectoris patients. [0003] The current methods of treating angina pectoris mainly focus on dilating blood vessels, reducing blood viscosity, anti-platelet aggregation, and anti-coag...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/20A61P9/10A61K31/045
Inventor 刘顺航徐波戚可人刘岩陈红丛德刚赵国辉
Owner TIANJIN TASLY MORDEN TCM RESOURCES
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