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Absorbable growth factor composite dressing

A growth factor, evenly mixed technology, used in absorbent pads, medical science, bandages, etc., can solve the problems of unstable growth factor biological activity, loss of growth factor biological activity, easy to produce heat-sensitive phenomenon, etc., to increase the adhesion function and Hemostatic effect, growth promotion, no heat-sensitive effect

Inactive Publication Date: 2011-04-13
广东弘和医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent: 99100585.6, titled "Sponge material for promoting the healing of spinal cord tissue injury and its preparation method and application", researched a mixture of collagen or collagen and chitin and added fibroblast growth factor-2 and nerve growth Factor sponge material, the use of this sponge material can accelerate the healing of damaged tissue wounds or injured surfaces, and the healing effect is good, but because the collagen used in this material is mostly animal collagen, heat-sensitive phenomena are prone to occur. The aqueous solution of factors is mixed into the mixing mechanism of collagen and chitin, and then freeze-dried
The half-life of the growth factor activity is only a few hours or less. Due to the simple mixing, the growth factors on the surface of the sponge material contact with the outside world, resulting in unstable biological activity of the growth factors, and the protease present at the wound site can degrade the growth factors. , it is easy to make the growth factor lose its biological activity

Method used

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  • Absorbable growth factor composite dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The composite dressing is a blended fiber made of modified hydroxyethyl cellulose and sodium alginate in a mass ratio of 5-15:5-15, stirred at high speed for 1 hour at room temperature to obtain a powder of the blended fiber, and stirred simultaneously , rapidly atomize and spray 0.02-0.05% of the RH-bFGF growth factor lyophilized powder solution of the total amount of composite cellulose, so that the RH-bFGF growth factor lyophilized powder solution is completely integrated into the matrix of the mixed fiber, and the blended fiber The matrix can swell rapidly when immersed in water. After swelling, a reticular gel is formed on the surface of the blended fiber matrix, forming an airtight and oxygen-free environment, which can be effectively isolated from the outside world and can maintain the activity of growth factors to the greatest extent, so that RH- The bFGF growth factor is embedded in the matrix, and then freeze-dried until the water is completely evaporated to co...

Embodiment 2

[0048] A composite dressing (hereinafter referred to as: Hemostatic effect of absorbable growth factor complex dressing).

[0049] Take 10 healthy mice (provided by Dongguan Institute of Drug Control), weighing 100-120 g, and randomly divide them into 2 groups, 5 mice in each group: (1) test group (absorbable growth factor compound dressing); (2) control group (common dressing). sterile gauze). The mice were anesthetized and injected with anesthesia, and a bleeding wound with a size of 1 cm × 0.5 cm was made on the back. The material of the test group was folded and spread on the wound surface to stop bleeding. At the same time, ordinary sterile gauze was used as a control, and the bleeding time was recorded.

[0050] result:

[0051] The hemostasis time of the test group was 1.85 (min), and that of the control group was 5.35 (min). The difference between the two groups was significant. The hemostasis time of the test group was shortened by 65%. The ability is better than t...

Embodiment 3

[0053] A composite dressing (hereinafter referred to as: Restorative effect of absorbable growth factor complex dressing).

[0054] Take 10 healthy mice (provided by Dongguan Drug Control Institute), weighing 100-120 g. The mice were anesthetized and injected with anesthesia, and a bleeding wound with a size of 1cm×0.3cm×0.3cm was made on the back, and the absorbable growth factor dressing was folded and applied on the surface of the wound with less pressure.

[0055] Observe the test group, 1 day, 4 days, 7 days, 10 days, the repair situation of the absorbable growth factor dressing in the body:

[0056]

[0057] Note: ① The appearance is complete, not degraded +++; the appearance is incomplete, partially degraded ++; the appearance is unclear, mostly degraded +; basically absorbed -.

[0058] ②Wound healing: 1%-100%

[0059] It can be seen that the absorbable growth factor composite dressing has good biocompatibility and can promote wound healing, because the RH-BFGF g...

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Abstract

The invention relates to an absorbable growth factor composite dressing which is mainly prepared from compound cellulose and growth factors, wherein the compound cellulose is prepared by compounding modified hydroxyethylcellulose and sodium alga acid. The dressing is prepared by compounding the modified hydroxyethylcellulose and the sodium alga acid to prepare the compound cellulose and then adding 0.02-0.05% of freeze-dried growth factor powder, and evenly mixing the compound cellulose with the powder. The dressing can promote rapid wound healing, shorten the treatment period and can be widely applied to various wounds comprising internal wounds and external wounds.

Description

technical field [0001] The invention relates to a medical dressing, in particular to an absorbable growth factor composite dressing, which belongs to the technical field of medical dressings. Background technique [0002] Clinically, local hemostasis is often performed on physical damage caused by surgery or accidental injury to prevent wound infection and accelerate wound healing. Regarding the hemostasis and healing of wounds, people have long discovered that wound-covering dressings have better healing effects than non-covering dressings, so people have conducted in-depth research on dressings, and there have been different types of dressings, of which traditional gauze dressings are the most influential. Power, and the application of the longest time, the market share is relatively large. [0003] With the rapid development of modern science and technology and the rapid development of various technical fields, traditional dressings that play a simple covering role can n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/44A61L15/28
Inventor 吴涛
Owner 广东弘和医疗科技有限公司
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