Blood-pressure noninvasive measuring device based on micro-bubble ultrasound contrast agents and measuring method thereof

Abstract

The invention discloses a blood-pressure noninvasive measuring device based on micro-bubble ultrasound contrast agents and a measuring method thereof. The measuring device comprises an ultrasonic probe, a transmitting module, a receiving module, a pressure-measuring position selecting module, a band-pass filter, a spectrum analyzer, a sub-harmonic optimal transmitting frequency calculating module, and a blood-pressure calculating and displaying module. The measuring method comprises the steps of: 1) infusing the micro-bubble ultrasound contrast agent solution into blood through veins and monitoring the track thereof by utilizing the diagnosis ultrasound, 2) collecting a sound scattered signal from the contrast agent when the contrast agent reaches the pressure-measuring position, 3) screening and performing spectrum analysis on the collected sound scattered signal so as to acquire the sub-harmonic optimal transmitting frequency, and 4) acquiring an environmental pressure according to a relational expression between the sub-harmonic optimal transmitting frequency and the environmental pressure. The invention can provide a more precise blood-pressure noninvasive measuring result with higher repeatability and reliability.

Description

Technical field [0001] The invention relates to a blood pressure non-invasive measurement device based on a microbubble ultrasound contrast agent and a measurement method thereof, belonging to the technical field of using ultrasound to measure blood pressure. Background technique [0002] Measuring the blood pressure in the heart cavity and large blood vessels can provide the health status of blood vessels and organs, and is an effective tool for clinicians to assess the condition of patients suffering from heart disease or vascular disease. At present, blood pressure is mainly measured by inserting a catheter with a pressure sensor into the heart cavity. This is an invasive blood pressure measurement method, which is often accompanied by pain, infection and even pulmonary artery damage, endocarditis and bleeding. In 1972, Burton applied the simplified Berlier equation to the ultrasound Doppler technique, which created a precedent for non-invasive measurement of intracardiac pre...

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Problems solved by technology

F.Forsberg, J.B.Liu, W.T.Shi, J.Furuse, M.Shimizu, B.B.Goldberg, "In vivo pressure estimation using subharmonic contrast microbubble signals: proof of concept," IEEE Transactions on Ultrasonics 52, 581-583 (2005) in vol. The experimental results show that the measurement results for multiple cardiac cycles are not consistent, and its repeatability needs to be further improved

In addition, the research results of K.S.Andersen, J.A.Jensen, "Ambient pressure sensitivity of microbubbles investigated through a parameter study," J.Acoust.Soc.Am.126, 3350-3358 (2009) showed that the amplitude of the subharmonic and the ambient pressure The relationship between them is not completely linear, which will affect the reliability of the results obtained by the linear calibration method

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