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Method for preparing novel fluorescent silica nanospheres

A technology of silicon dioxide and nanospheres, applied in chemical instruments and methods, luminescent materials, etc., can solve the problems of environmental damage, limited biological application of semiconductor quantum dots, and large cell damage, and achieves easy operation, wide range of luminescent wavelengths. Tuning and fluorescence stabilization

Inactive Publication Date: 2011-02-16
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, fluorescent semiconductor quantum dots are mainly composed of group II / VI and group III / V elements, usually core-shell nanobody with CdSe as the core and CdS or ZnS as the shell. Or in vitro test, heavy metal Cd 2+ The release of large amount of damage to cells, especially in living biological cell labeling; coupled with the potential damage to the environment, these have seriously limited the biological application of semiconductor quantum dots

Method used

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  • Method for preparing novel fluorescent silica nanospheres
  • Method for preparing novel fluorescent silica nanospheres
  • Method for preparing novel fluorescent silica nanospheres

Examples

Experimental program
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Effect test

Embodiment 1

[0028] In this embodiment, the preparation steps of fluorescent silica nanospheres are as follows:

[0029] 1. Preparation of octadecylamine-modified fluorescent carbon quantum dots

[0030] (1) Preparation of fluorescent carbon quantum dots

[0031] Prepared according to the disclosed prior art, adopt 1.0g disodium ethylenediaminetetraacetic acid (EDTA-2Na), put it in a quartz boat, put it into a tube furnace and calcinate it at 380°C for 2 hours under the protection of nitrogen to obtain Fluorescent carbon quantum dots;

[0032] (2) Modification of fluorescent carbon quantum dots with octadecylamine

[0033] Dissolve 0.5g of fluorescent carbon quantum dots in 30mL of water, ultrasonically disperse, and then centrifuge, take 20mL of its supernatant, adjust the pH value of the solution to 5.5 with acetic acid; then add 0.5g of octadecylamine and 20mL of supernatant to the supernatant Toluene, mixed evenly; then pour the above mixed solution into the reaction kettle, and rea...

Embodiment 2

[0042] The implementation process steps are all the same as in Example 1 except for the following differences.

[0043] Measure 40mL of ethanol (CH 3 CH 2 OH) into the solution and mix well, then slowly add 1mL ammonia water (NH4 OH), 1 mL tetraethyl orthosilicate (TEOS), and stirred at 40°C for 1 hour.

[0044] In step (3), 1 mL of TEOS and 0.5 g of cetyltrimethylammonium bromide (CTAB) were gradually and slowly added to the solution, and after slow stirring for 1 hour, the lower layer was centrifuged with a high-speed centrifuge to remove the precipitate.

[0045] The result is basically similar to Example 1, the difference is that fluorescent SiO 2 The shell portion of the nanospheres is slightly thinner than Example 1 in thickness.

Embodiment 3

[0047] The implementation process steps are all the same as in Example 1 except for the following differences.

[0048] In step (2), measure 40 mL of ethanol (CH 3 CH 2 OH) into the solution and mix well, then slowly add 1mL ammonia water (NH 4 OH), 4 mL tetraethyl orthosilicate (TEOS), and stirred at 40°C for 12 h.

[0049] In step (3), 4 mL of TEOS and 1.5 g of cetyltrimethylammonium bromide (CTAB) were gradually and slowly added to the solution, and after the reaction was stirred slowly for 12 hours, the lower layer was centrifuged with a high-speed centrifuge to remove the precipitate.

[0050] The result is similar to Example 1, the difference is that fluorescent SiO 2 Both the core part and the shell part of the nanosphere are slightly thicker than that of Example 1, and the fluorescence performance is slightly weakened.

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Abstract

The invention relates to a method for preparing fluorescent silica nanospheres and belongs to the technical field of inorganic chemistry and material synthesis. The main process of the method of the invention mainly comprises: (1) according to the prior art, calcining a certain amount of ethylene diamine tetraacetic acid (EDTA-2Na) at 250 to 400 DEG C in the presence of N2 in a tube furnace to obtain fluorescent carbon quantum dots; (2) mixing the fluorescent carbon quantum dots, deionized water, octadecylamine and methylbenzene, reacting at 160 to 180 DEG C for 12 hours, centrifuging, separating, collecting supernate and drying to obtain octadecylamine-modified fluorescent carbon quantum dots; and (3) mixing the octadecylamine-modified fluorescent carbon quantum dots with water, ethanol,ammonia water and ethyl orthosilicate, reacting at 40 DEG C for 1 to 12 hours, adding the ethyl orthosilicate and the hexadecy ltrimethyl ammonium bromide, reacting for 1 to 12 hours, washing with ethanol, centrifuging, drying and calcining at 300 DEG C for 3 hours and thus obtaining the fluorescent silica nanospheres.

Description

technical field [0001] The invention relates to a method for preparing fluorescent silica nanospheres, in particular to a method for preparing a composite material of silica-coated fluorescent carbon quantum dots, and belongs to the technical field of inorganic chemistry and material synthesis. Background technique [0002] In the past ten years, semiconductor quantum dots (Quantum dots) have attracted attention because of their unique optical properties such as size-tunable fluorescence emission, narrow and symmetrical emission spectrum, wide and continuous absorption spectrum, and excellent photostability. Widely concerned, it is expected to replace organic dye probes as a new generation of excellent fluorescent probes, and will play an important role in future probe labeling detection technologies and related research. However, fluorescent semiconductor quantum dots are mainly composed of group II / VI and group III / V elements, usually with CdSe as the core and CdS or ZnS a...

Claims

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Application Information

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IPC IPC(8): C09K11/65C09K11/02
Inventor 张海娇焦正李智勇吴明红潘登余张云龙
Owner SHANGHAI UNIV
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