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Use of hirsutine in preparing anti-addictive drug

A technology for rhynchophylline and medicine, which is applied in the field of pharmaceutical preparations and can solve problems such as no preparations being listed on the market.

Active Publication Date: 2012-05-30
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But for the purposes of rhynchophylline in the prevention and treatment of drug addiction and withdrawal, so far, there is no relevant report, and there is no use of rhynchophylline as the main raw material to treat drug dependence and withdrawal of opioids and amphetamines. Drugs for treating symptoms are on the market

Method used

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  • Use of hirsutine in preparing anti-addictive drug
  • Use of hirsutine in preparing anti-addictive drug
  • Use of hirsutine in preparing anti-addictive drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] Commercially available rhynchophylline is relatively rare, so the inventor refers to Xin Wenbo et al. in "Research on Uncaria Alkaloids Components" (Xin Wenbo, et al. Research on Uncaria Alkaloids Components. Chinese Herbal Medicine, 2009, 40 (2): 204 -207) The method disclosed in the article extracts rhynchophylline, and the specific steps are as follows:

[0083] Take Uncaria medicinal material, crush it into a coarse powder, cold soak with 95% ethanol for 24 hours, put it into a percolation cylinder and extract it by percolation. Collect the percolation liquid, recover the ethanol under reduced pressure and then concentrate to obtain the extract, which is dissolved with 3% hydrochloric acid solution and filtered. The filtrate was basified with ammonia water, heated and refluxed with ether to extract several times, the solvent was recovered, and filtered to obtain ether extract. The sample was loaded on a silica gel column (300 mesh), eluted with petroleum ether-ethy...

Embodiment 2

[0086] formula:

[0087] The rhynchophylline 20g that embodiment 1 obtains

[0088] Dextrin 20g

[0089] Starch 57g

[0090] Micronized silica gel 3g

[0091] Preparation method: adopt the preparation process in Example 1 to prepare rhynchophylline, freeze-dry and pulverize to obtain freeze-dried powder, add starch, dextrin and micropowder silica gel according to the above dosage, fully mix the main and auxiliary drugs and pass through a 100-mesh sieve , granulated, dried at low temperature, granulated, compressed into tablets, film-coated, and made into film-coated tablets. Each tablet contains 10mg of rhynchophylline.

[0092] Dosage: Take orally, 3 tablets at a time, 3-4 times a day.

Embodiment 3

[0094] formula:

[0095] The rhynchophylline 50g that embodiment 1 obtains

[0096] Dextrin 17g

[0097] Starch 30g

[0098] Micronized silica gel 3g

[0099] Preparation method: adopt the preparation process in Example 1 to prepare rhynchophylline, freeze-dry and pulverize to obtain freeze-dried powder, add sugar powder, starch, micronized silica gel and magnesium stearate according to the above dosage, and mix the main and auxiliary ingredients well Afterwards, sieve, granulate, granulate, mix evenly, pack into capsules, and make capsules. Each capsule contains 25mg of rhynchophylline.

[0100] Dosage: Take orally, 2 capsules at a time, 2-3 times a day.

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Abstract

The invention relates to a drug containing a heterocyclic system of a hexatomic ring with nitrogen as a heteroatom, in particular to an application of hirsutine in preparing a drug for preventing and treating opioid substance addiction or amphetamine substance dependence. The drug is composed of the hirsutine and a pharmaceutically acceptable auxiliary material, wherein, the hirsutine content is 5-85%. The drug is oral preparation such as a tablet or a capsule and the like.

Description

technical field [0001] The present invention relates to pharmaceutical preparations containing organic active ingredients, in particular to medicines with a six-membered ring heterocyclic system containing nitrogen as a ring heteroatom. Background technique [0002] At present, the globalized drug problem has posed a major threat to the survival and development of mankind. Traditional narcotics represented by opioids and new drugs represented by amphetamine-type stimulants (Amphetamine-type Stimulants, ATS) are the main drugs of abuse. At present, the commonly used methods of detoxification at home and abroad are mainly drug treatment. For the treatment of opioid addiction, there are mainly opioid substitution methods, such as methadone replacement therapy. The drug treatment for ATS abuse addicts is mostly symptomatic, such as the use of tricyclic antidepressants, antipsychotic drugs, sedative and hypnotics, etc. Because most of the above chemically synthesized drugs hav...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4375A61P25/36A61P25/30
Inventor 莫志贤翁建霖
Owner SOUTHERN MEDICAL UNIVERSITY
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