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Lipoid acid composition for injection

A technology of lipoic acid and composition, applied in the field of lipoic acid composition for injection, can solve problems such as unsatisfactory effect, increasing the effect of lipoic acid stability, and increasing the dosage of injection

Active Publication Date: 2011-02-02
南通集智知识产权服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Disclosed a kind of lipoic acid injection as German patent application EP0318891 in 1992, lipoic acid is mixed with tromethamine and arginine, there is bigger defect in this injection, on the one hand arginine consumption is big (in the unit medicine) 30% arginine is needed (calculated in moles), and the content of lipoic acid in unit molar injections is relatively low, which leads to the need to increase the dosage of injections during clinical use; on the other hand, the prescription increases the stability of lipoic acid and does not unsatisfactory
Chinese patent application CN200510025601 discloses a lipoic acid freeze-dried powder injection. The solution adopted is to modify the existing injection on the market. The preparation process of the freeze-dried powder injection is more complicated than that of the injection, and the preparation cost is increased.

Method used

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  • Lipoid acid composition for injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Alpha Lipoic Acid 3g

[0025] Tromethamine 3g

[0026] Methionine 0.07g

[0027] Under the conditions of nitrogen and light protection, take the above amount of tromethamine and add appropriate amount of water to dissolve it, then add lipoic acid and methionine in turn, mix and stir evenly, add water for injection to 100ml, and pass through a 0.22um microporous membrane After filtration, it was packaged into 20 bottles and sterilized at 121°C for 20 minutes.

Embodiment 2

[0029] Alpha Lipoic Acid 5g

[0030] Tromethamine 7g

[0031] Sodium hydroxide 0.2g

[0032] Methionine 0.15g

[0033] Arginine 0.15g

[0034] Under the condition of nitrogen and avoiding light, take the above-mentioned amount of tromethamine and add appropriate amount of water to dissolve it, then add lipoic acid, methionine, arginine, sodium hydroxide in turn, mix and stir evenly, add water for injection to 200ml, After being filtered through a 0.22um microporous membrane, it was packaged into 20 bottles and sterilized at 121°C for 20 minutes.

Embodiment 3

[0036] Alpha Lipoic Acid 3g

[0037] Tromethamine 3g

[0038] Methionine 0.1g

[0039] Arginine 0.05g

[0040] Under the condition of nitrogen and avoiding light, take the above amount of tromethamine and add appropriate amount of water to dissolve it, then add lipoic acid, methionine, and arginine in turn, mix well, add water for injection to 100ml, and pass through 0.22um After filtering with a microporous membrane, it was packaged into 20 bottles and sterilized at 121°C for 20 minutes.

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Abstract

The invention discloses a lipoic acid composition for injection, which is an injection and comprises the components of lipoic acid, a compatibilizer and an antioxidant. The disclosed lipoic acid composition has high stability by taking methionine as the antioxidant.

Description

technical field [0001] The invention relates to a lipoic acid composition, and further relates to a lipoic acid composition for injection, which contains lipoic acid, a solubilizer and an antioxidant, and belongs to the field of medicine. Background technique [0002] Alpha lipoic acid is a natural product isolated from pig liver. Studies have found that it has excellent antioxidant effects and is known as a universal antioxidant. In recent years, a number of studies have found that lipoic acid has preventive and therapeutic effects on various diseases related to active oxidative free radicals, such as diabetes, heavy metal poisoning, radiation damage, and degenerative neuropathy. Diabetes is a comprehensive metabolic disorder. Diabetic peripheral neuropathy is the most common complication of chronic diabetes, which seriously affects the quality of life of patients. Experiments have confirmed that lipoic acid supplementation can increase the blood flow of endoneurium, incre...

Claims

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Application Information

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IPC IPC(8): A61K31/385A61K9/08A61P25/02A61P39/06A61P3/10A61K47/16
Inventor 王雷波郝守祝
Owner 南通集智知识产权服务有限公司
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