Drug combination with antiinflammatory action and abirritation and preparation method and application thereof

A kind of technology of anti-inflammatory and analgesic composition, applied in the field of pharmaceutical composition and preparation thereof

Active Publication Date: 2011-01-12
TIBET QIZHENG TIBETAN MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no medicine for anti-inflammation and analgesia by using the pharmaceutical composition composed of homogenin hydrobromide and the effective fraction of unique flavonoids

Method used

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  • Drug combination with antiinflammatory action and abirritation and preparation method and application thereof
  • Drug combination with antiinflammatory action and abirritation and preparation method and application thereof
  • Drug combination with antiinflammatory action and abirritation and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0168]Embodiment 1: pharmaceutical composition tablet of the present invention

[0169] 15g of quinine hydrobromide and 95g of unique flavonoids;

[0170] A. the preparation method of homogenate hydrobromide:

[0171] Take the dried Aconitum medicinal material, crush it, soak it with 10 times by weight of 75% ethanol for 144 hours, collect the soaking solution, and continue percolation with 10 times the weight of ethanol, collect the percolation solution, and combine the soaking solution and the percolation solution to obtain a mixed solution , and recover ethanol until there is no alcohol smell, add 1.5% hydrochloric acid to acidify to PH2, and filter to obtain an acidified solution; add ammonia water to alkalize the acidified solution to pH10 to obtain an alkalized solution; Dehydrate phosphorus oxide, recover chloroform, and obtain the extract; add 95% ethanol to the extract and let it stand for crystallization for 42 hours, wash with 95% ethanol, and filter to obtain urin...

Embodiment 2

[0175] Embodiment 2: pharmaceutical composition capsule of the present invention

[0176] 95g of quinine hydrobromide and 15g of unique flavonoids;

[0177] A. the preparation method of homogenate hydrobromide:

[0178] Take the dried Aconitum medicinal material, crush it, soak it with 5 times by weight of 95% ethanol for 276 hours, collect the soaking solution, and continue percolating with 5 times the weight of ethanol, collect the percolation solution, and combine the soaking solution and the percolation solution to obtain a mixed solution , and recover ethanol until there is no alcohol smell, add 9% hydrochloric acid to acidify to PH1, and filter the acidified solution; pass the acidified solution through a cation exchange resin, first elute with water until the eluent is colorless, then use 45% ethanol to analyze, absorb , The flow rate of washing and analysis is 3 times the bed volume / hour, collect the ethanol solution, reclaim the ethanol until there is no alcohol smel...

Embodiment 3

[0182] Embodiment 3: pharmaceutical composition powder of the present invention

[0183] 50g of quinine hydrobromide and 50g of unique flavonoids;

[0184] A. the preparation method of homogenate hydrobromide:

[0185] Take the dried Aconitum medicinal material, crush it, soak it with 20 times by weight of 65% ethanol for 96 hours, collect the soaking solution, and continue to percolate with 20 times the weight of ethanol, collect the percolation solution, and combine the soaking solution and the percolation solution to obtain a mixed solution , and reclaim ethanol until there is no alcohol smell, add 1% hydrochloric acid to acidify to PH3, and filter to obtain an acidified solution; add ammonia water to alkalize the acidified solution to pH9 to obtain an alkalized solution; Dehydrate phosphorus oxide, recover chloroform, and obtain the extract; add 85% ethanol to the extract and let it stand for crystallization for 24 hours, wash with 85% ethanol, and filter to obtain homoge...

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Abstract

The invention provides a drug combination with antiinflammatory action and abirritation, which is prepared by lappaconitine hydrobromide and lamiophlomis rotate flavone as bulk pharmaceutical chemicals. In the invention, pharmacological research on the mutual effect and the compatibility of medicines of the lappaconitine hydrobromide and the lamiophlomis rotate flavone is carried out. The result shows that the drug combination of the invention can obviously improving the threshold value of mice compared with the situation that lappaconitine hydrobromide or the lamiophlomis rotate flavone is respectively used. The drug combination of the invention is subject to a mouse acetic acid writhing test, a mouse hot-water bath tail flick test, a rat carrageenin paw swelling test and a mouse auricle swelling test caused by dimethyl benzene so as to obtain the optimal formula of the drug combination. The drug combination of the invention has obvious antiinflammatory action and abirritation and has wide application prospects.

Description

field of invention [0001] The present invention relates to a pharmaceutical composition and its preparation method and use, in particular to a drug with anti-inflammatory and analgesic effects, which uses the effective part of aconitum aconitum hydrobromide and the effective part of Duyiwei flavonoids as ingredients. The pharmaceutical composition of the raw material drug and its preparation method and use. Background technique [0002] Aconitum aconitum is the dry root of Aconitum Sinomontanum Nakai, a plant of the Ranunculaceae family. It is excavated in autumn, and the fibrous roots and aerial parts are removed, and the soil is washed away and dried in the sun. Distributed in Xiaowutai Mountain, Yuxian County, Hebei Province, Shanxi, counties east of Riyue Mountain in Qinghai, Shaanxi, Gansu, Hubei, Sichuan and Guizhou provinces. Its root is poisonous, used as medicine, can reduce swelling and pain, promote blood circulation and dissipate blood stasis, expel wind, has st...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61P29/00A61K31/439
Inventor 李智勤张国霞张樱山路杰
Owner TIBET QIZHENG TIBETAN MEDICINE
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