A kind of etofenamate patch

A technology of etofenamate and ester patches, which can be applied in the directions of anti-inflammatory agents, non-central analgesics, drug combinations, etc., and can solve problems such as general effects and the like

Active Publication Date: 2020-06-23
安徽天耘医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although there is a patch of etofenamate in the prior art, the effect is general

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Mix 5% etofenamate, 4% dodecylamine, 4% papain and silicone pressure-sensitive adhesive matrix evenly, coat on the anti-adhesive layer, compound with the backing layer after drying, and cut into patches.

Embodiment 2

[0016] Mix 4% etofenamate, 6% dodecylamine, 2% papain and silicone pressure-sensitive adhesive matrix evenly, coat on the anti-adhesive layer, compound with the backing layer after drying, and cut into patches.

Embodiment 3

[0018] Mix 5% etofenamate, 8% dodecylamine, 1% papain and silicone pressure-sensitive adhesive matrix evenly, coat on the anti-adhesive layer, compound with the backing layer after drying, and cut into patches.

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Abstract

The invention relates to an etofenamate patch, and belongs to the field of a medicine preparation. A medicine carrying layer of the etofenamate patch contains etofenamate and a penetration enhancer prepared from 0.5 to 10 percent of dodecyl amine and 0.1 to 4 percent of papain; the medicine carrying layer is also prepared from a surfactant, an emulsifying agent, a humectant, a preservative or an antioxidant and the balance of silicone pressure sensitive adhesives; in addition, the etofenamate patch also comprises a backing layer and an anti-sticking layer. The result shows that compared with commercially available etofenamate patch and commercially available gelatin, the etofenamate patch has the advantages that the inhibition percentage on the body twisting caused by mouse acetate inflammation is higher; the condition shows that the anti-inflammatory and analgesic effects are better.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to an etofenamate patch. Background technique [0002] Etofenamate (Etofenamate) is an acid-type non-steroidal anti-inflammatory drug, which can inhibit cyclooxygenase and ester oxidase, reduce the effects of prostaglandins and other inflammatory mediators, thereby exerting anti-inflammatory and analgesic effects. It can be transdermally absorbed when applied on the skin, and its pharmaceutical active ingredients can be effectively transferred to the inflammation site, reduce local swelling and have good tolerance. After oral administration to experimental animals, its anti-inflammatory effect is better than that of flufenamic acid and phenylbutazone, but it has certain adverse reactions of causing peptic ulcer. It can inhibit the release and effect of bradykinin, cyclooxygenase, histamine, 5-hydroxytryptamine, hyaluronic acid and total complement, stabilize the lysosomal...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K47/42A61K47/18A61K31/216A61P29/00
CPCA61K9/0014A61K9/7023A61K31/216A61K47/18A61K47/42
Inventor 李培耀
Owner 安徽天耘医疗器械有限公司
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