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Application of cytotoxin (CTX1) from snake venom to preparation of medicament for rehabilitating

A technology of -CTX1 and cytotoxin, applied in the field of application of cytotoxin-CTX1 in the preparation of detoxification drugs, to achieve significant drug effects, eliminate thirsty drug behavior, improve functional status and diet and activity effects

Inactive Publication Date: 2010-12-29
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether CTX1 has the function of detoxification has not been reported so far

Method used

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  • Application of cytotoxin (CTX1) from snake venom to preparation of medicament for rehabilitating
  • Application of cytotoxin (CTX1) from snake venom to preparation of medicament for rehabilitating
  • Application of cytotoxin (CTX1) from snake venom to preparation of medicament for rehabilitating

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: Effects of different doses of CTX1 on the formation of CPP by morphine

[0028] After the rats produced a stable CPP to morphine, they were given CTX10.1, 0.2, and 0.4 mg / kg doses respectively for 8 days, and at d11, the CTX10.2 mg / kg and 0.4 mg / kg dose groups were compared with the morphine control group and the given doses. There was a significant difference between before and after CTX1 (P<0.05~0.01). After 8 days of continuous administration of CTX1, each CTX1 dose group no longer had a preference or even aversion to the medicine box. CTX1 inhibits the CPP induced by morphine in rats (Table 1), indicating that it has a good detoxification effect on the thirsty behavior and reward effect of animals addicted to morphine.

[0029] Table 1: Effects of different doses of CTX1 on cpp in morphine addiction

[0030]

Control group (normal saline)

model group

CTX1 low dose group (0.1mg / kg)

CTX1 middle dose group (0.2mg / kg)

CTX1 high ...

Embodiment 2

[0033] Example 2: The addictive effect of CTX1 on naloxone

[0034] Rats in each experimental group in Example 1 were injected intraperitoneally with 5 mg / kg naloxone to induce addiction on d18, observed for 40 minutes, and recorded and scored withdrawal symptoms (Table 2). Statistical analysis showed that there was a significant difference between the morphine group and other groups (P0.05). This result shows that CTX1 is not a substitute for morphine-like addictive drugs to exert its detoxification effect.

[0035] Table 2 The addictive effect of naloxone on the model group and CTX1 dose groups (x±s, n=8)

[0036]

[0037] ■P<0.01, vs 0.9%N.S control group ※P<0.01, vs CTX1 group ●P<0.05 vs 0.9%N.S control group andCTX1group

Embodiment 3

[0038] Example 3: The effect of CTX1 treatment on the body weight of addicted rats

[0039] After the rats were given morphine for conditioned place preference training for 8 consecutive days, the weight of the rats increased significantly less than that of the normal saline group treated in the same way, indicating that the rats had become dependent on morphine and affected the weight gain. Addicted rats were continuously given different doses of CTX for 18 days, and their body weight increased to varying degrees (Table 3). Among them, the body weight of the CTX10.2mg / kg and CTX10.4mg / kg dose groups increased significantly compared with that of CTX10.1mg / kg, respectively reaching 132.3± 2.0% and 139.2±3.7%, significantly different from the morphine group (p<0.01). The results show that: CTX1 can improve the body weight of morphine-dependent rats, improve their mental activity and diet, and there is a certain dose-effect relationship.

[0040] Table 3 Effect of CTX1 on body w...

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Abstract

The invention discloses application of cytotoxin (CTX1) from snake venom to preparation of a medicament for rehabilitating. Proved by the experiment, the CTX1 can better eliminate the behavioral sensitization of addict rats by morphine, eliminate the medicament thirst behavior and the abstinence syndrome of rats and has favorable rehabilitating effect. In addition, the invention can improve the function state, the diet and the activities of the addict rats and remarkably increase the weight, thereby recovering normal physiological activity.

Description

technical field [0001] The invention relates to the application of the cytotoxin-CTX1 derived from snake venom, in particular to the application of the cytotoxin-CTX1 derived from snake venom in the preparation of drugs for detoxification. Background technique [0002] Snake venom is a huge treasure house of biological resources. Since 1968, British scientists first successfully developed ARIN, a snake venom preparation for the treatment of vascular occlusive diseases, and soon after it was put on the market, it gained huge economic returns. In the past ten years, with the emergence of as many as dozens of snake venom drugs, and achieved good clinical curative effect and sales performance, the development of cheap and high-quality specific drugs from snake venom is becoming a popular choice for biologists, pharmacists and experts from all over the world. A new hotspot that pharmaceutical companies are scrambling to pursue. [0003] The Zhoushan cobra (Naja atra Cantor), wi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61P25/36
Inventor 刘先国孔天翰信文君仲维高崔跃董伟华黄绍崔超伟唐娅
Owner SUN YAT SEN UNIV
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