Lung adenocarcinoma serum marker protein

Abstract

The invention relates to early diagnosis of lung adenocarcinoma, in particular to a lung adenocarcinoma serum marker protein, and meanwhile provides a screening method, a related decision tree model and a detection method thereof. The screening method comprises the following steps of: detecting serum protein differential expressions of a lung adenocarcinoma patient and a healthy control by adopting an SAX-2 protein chip, screening 102 differential mass spectrum peaks (p is less than 0.001), establishing a lung adenocarcinoma protein mass spectrogram, screening two proteins m / z14022.9 and m / z3735.99 with least p values, and establishing the decision tree model for the two proteins, wherein both the two proteins have very good distinguishing capabilities, the diagnosed lung adenocarcinoma can be obtained by the participation of the two proteins in the decision tree model, the accuracy of the two proteins is 98.387 percent, and a blind test discovers that the accuracy, sensitivity and specificity of diagnosing the lung adenocarcinoma are 100 percent.

Description

Technical field: [0001] The invention relates to early diagnosis of lung adenocarcinoma, in particular to a lung adenocarcinoma serum marker protein, its screening method, its related decision tree model and its detection method. Background technique: [0002] Lung adenocarcinoma is one of the common malignant tumors in clinic. Lung adenocarcinoma patients generally have no obvious symptoms in the early stage, 70% to 80% of the patients are already in the advanced stage when they see a doctor, and the 5-year survival rate is less than 10%. Very early diagnosis or early diagnosis is crucial for successful treatment of lung adenocarcinoma, improved prognosis and increased patient survival. A large number of studies have shown that the occurrence of lung adenocarcinoma has nothing to do with smoking, and its mortality rate is very high. Therefore, the very early diagnosis and very early treatment of lung adenocarcinoma has become a research hotspot at home and abroad. [0003...

AI Technical Summary

Problems solved by technology

[0008] At present, the specificity and sensitivity of serum markers related to lung cancer, especially lung adenocarcinoma, are low. Therefore, clinical medicine urgently needs to find new serum markers related to lung adenocarcinoma with high accuracy, sensitivity and specificity.

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