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Trimeric binding proteins for trimeric cytokines

A technology of cytokines and binding elements, applied in anti-cytokine/lymphokine/interferon immunoglobulin, receptor of cytokine/lymphokine/interferon, anti-receptor/cell surface antigen/cell surface determinant immunity The direction of globulin can solve the problem of not being able to effectively block the 3 receptor binding sites

Inactive Publication Date: 2010-12-01
ANAPHORE INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] However, a common technical problem encountered with currently known trimeric cytokine conjugates and inhibitor products is that after formation of the 1:1 complex of the trimeric cytokine and the conjugate or inhibitor product, Cannot effectively block all 3 receptor binding sites of trimeric cytokines because at least 1 or 2 of the 3 receptor binding sites are still open

Method used

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  • Trimeric binding proteins for trimeric cytokines
  • Trimeric binding proteins for trimeric cytokines
  • Trimeric binding proteins for trimeric cytokines

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Embodiment Construction

[0024] In one aspect, the present invention provides a trimeric conjugate capable of binding trimeric cytokines, preferably in a manner such that after binding, it can substantially block and / or neutralize all receptor binding sites of the trimeric cytokine , Thereby inhibiting or neutralizing the potential biological activity of trimeric cytokines. Therefore, a trimeric polypeptide comprising 3 monomers is provided, wherein each monomer contains a specific binding member capable of binding trimerizing cytokines, and each monomer contains a trimerization domain.

[0025] As used herein, the term "trimeric cytokine" refers to small proteins and their fragments, which are produced and secreted by cells, which can cause specific reactions in cells that have receptors for the cytokine, such as affecting cell growth, Split and / or function. The term "trimeric" herein means that the cytokine of the present invention exists as a multi-subunit complex containing 3 subunits, preferably 3 ...

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Abstract

The present invention pertains to the provision of trimeric binding units which bind to trimeric cytokines. In particular there is provided a trimeric polypeptide comprising a trimerising domain and three monomers with binding members capable of binding a trimeric cytokine. Preferably, the trimeric binding units bind in a manner such that upon binding, all receptor binding sites of the trimeric cytokine are substantially blocked, and hence the potential biological activity of the trimeric cytokine is suppressed. In one aspect the invention relates to trimeric binders capable of binding to trimeric cytokines of the Tumor necrosis factor ligand superfamily, such as TNF, TRAIL, RANKL, TWEAK, APRIL and BAFF.

Description

[0001] This application is a divisional application for the invention patent application with the filing date of October 29, 2003, the application number of 2003800104658.7, and the title of the invention "trimeric binding protein of trimeric cytokine". Technical field [0002] The present invention provides trimeric binding proteins capable of binding trimeric cytokines. More specifically, a trimeric binder that can bind in a certain way is provided, so that after binding, it can substantially block all receptor binding sites of the trimeric cytokine, thereby inhibiting the trimeric cytokine Potential biological activity. In one aspect, the present invention relates to trimeric conjugates that can bind to cytokines of the tumor necrosis factor ligand superfamily, including tumor necrosis factor (TNF). Background technique [0003] Cytokines are small polypeptides secreted by higher eukaryotes, which are responsible for signal transduction between cells and affect the growth, div...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/525C07K14/725C07K16/30A61K38/19A61P19/02A61P19/04A61P29/00A61P17/06A61P1/00A61K38/00C07K14/715C07K16/24C12N5/28C12N15/62G01N33/68
CPCC07K16/241C07K2317/622C07K14/715C07K2319/73A61K38/00C07K14/7151C07K14/525C12N15/62G01N33/6863C07K2317/24A61P1/00A61P17/06A61P19/02A61P19/04A61P29/00
Inventor T·L·霍尔帝特M·H·安德森H·K·奥托
Owner ANAPHORE INC
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