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Chinese medicinal compound preparation arsenic tetrasulfide-tanshinone-indirubin and preparation method thereof and application thereof in preparing antineoplastic agents

A compound preparation and traditional Chinese medicine technology, applied in the field of biomedicine, can solve the problems of high complications and mortality, and limit the application of elderly MDS patients, and achieve the effect of improving absorption

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Problems solved by technology

[0024] Myelodysplastic syndrome (Myelodysplastic Syndrome MDS) is a bone marrow hematopoietic stem cell disease that often occurs in the elderly. The quality and quantity of bone marrow hematopoietic cells develop abnormally, resulting in pathological hematopoiesis, while the peripheral blood manifests as primary, secondary or complete A group of malignant clonal diseases characterized by cytopenia, dependence on blood transfusion and progression to acute leukemia have no effective treatment except allogeneic bone marrow transplantation, but allogeneic bone marrow transplantation is limited by donor sources, and transplant-related complications and mortality Very high, limiting its application in elderly MDS patients

Method used

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  • Chinese medicinal compound preparation arsenic tetrasulfide-tanshinone-indirubin and preparation method thereof and application thereof in preparing antineoplastic agents
  • Chinese medicinal compound preparation arsenic tetrasulfide-tanshinone-indirubin and preparation method thereof and application thereof in preparing antineoplastic agents
  • Chinese medicinal compound preparation arsenic tetrasulfide-tanshinone-indirubin and preparation method thereof and application thereof in preparing antineoplastic agents

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Experimental program
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Effect test

preparation Embodiment 1

[0067] The powders of tetraarsenic tetrasulfide, indirubin and tanshinone IIA are uniformly mixed at a weight ratio of 5:1:1, and starch is added to make capsules. The dosage unit contains 250 mg of arsenic tetrasulfide, 50 mg of indirubin and 50 mg of tanshinone IIA.

preparation Embodiment 2

[0069] The powders of tetraarsenic tetrasulfide, indirubin and tanshinone IIA are uniformly mixed at a weight ratio of 1:1:1, added with dextrin, and pressed into tablets. The dosage unit contains 50 mg of arsenic tetrasulfide, 50 mg of indirubin and 50 mg of tanshinone IIA.

preparation Embodiment 3

[0071] The powders of tetraarsenic tetrasulfide, indirubin and tanshinone IIA are uniformly mixed at a weight ratio of 10:1:1, and starch is added to prepare granules. Its dosage unit contains 250 mg of arsenic tetrasulfide, 25 mg of indirubin and 25 mg of tanshinone IIA.

[0072] Test Example

[0073] The present invention achieves the purpose of treating acute promyelocytic leukemia (AML M3) by inhibiting leukemia cell proliferation and inducing leukemia cell apoptosis through the compound Chinese medicine preparation arsenic indigo ginseng ATI; the compound Chinese medicine preparation arsenic indigo ginseng ATI down-regulates CDK2, reduces phosphorylated histone H1 Up-regulate P27, inhibit cells from G1 to S phase, up-regulate P27Rb, inhibit cells from entering S phase, thereby inhibiting tumor cell proliferation, and achieve the treatment of chronic myeloid leukemia, myelodysplastic syndrome, multiple myeloma, liver cancer, lung cancer, gastric cancer, The purpose of sol...

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Abstract

The invention relates to a Chinese medicinal compound preparation arsenic tetrasulfide-tanshinone-indirubin and a preparation method thereof and application thereof in preparing antineoplastic agents. The Chinese medicinal compound preparation comprises the active ingredients of arsenic tetrasulfide, indirubin and tanshinone IIA in a weight ratio of 1-10:1:1. The Chinese medicinal compound preparation arsenic tetrasulfide-tanshinone-indirubin can be applied to the preparation of the antineoplastic agents. Pharmacological experiment results show that the Chinese medicinal compound preparation arsenic tetrasulfide-tanshinone-indirubin can treat various neoplastic diseases.

Description

technical field [0001] The invention relates to the field of biomedicine, especially tetraarsenic tetrasulfide As 4 S 4 (A), tanshinone IIA (T), and indirubin (I), a traditional Chinese medicine compound preparation arsenic indigo, its preparation method and its application in the preparation of antineoplastic drugs. Background technique [0002] Leukemia is a group of hematopoietic stem / progenitor cell diseases with abnormal genome. According to the natural course of the disease and the maturity of leukemia cells, it is divided into acute leukemia and chronic leukemia. According to different cell series, acute leukemia is divided into acute lymphocytic leukemia (Acute Lymphoid Leukemia, ALL) and acute myeloid leukemia (Acute Myeloid Leukemia, AML), the latter is divided into several subtypes M0 ~ M7; chronic leukemia is divided into subtypes Chronic Myeloid Leukemia (CML) and Chronic Lymphoid Leukemia (CLL). [0003] In 1976 and 1985, the Anglo-French-American Cooperativ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/04A61P35/00A61P35/02A61K31/404A61K31/58
Inventor 陈竺陈赛娟王兰周光飚刘舒畅刘萍
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