Process for preparing bupleurum chinense injection

A technology of injection and Bupleurum, applied in the field of preparation of Bupleurum injection, can solve problems such as low volatile oil content of Bupleurum, poor product stability, toxic and side effects, etc., and achieve the effects of avoiding toxic and side effects, improving stability, and high bioavailability

Active Publication Date: 2010-11-17
SICHUAN DE PEI YUAN TRADITIONAL CHINESE MEDICINE SCI & TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] The purpose of the present invention is to overcome the disadvantages of Bupleurum bupleuri injection in the prior art that the process is backward, the content of bupleurum volatile oil is low, the product stability is relatively poor, and the auxiliary material polysorbate 80 has certain toxic and side effects, and an improved bupleurum bupleuri is provided. Preparation method of injection

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  • Process for preparing bupleurum chinense injection
  • Process for preparing bupleurum chinense injection
  • Process for preparing bupleurum chinense injection

Examples

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Effect test

Embodiment 1

[0047] Bupleurum injection in the present embodiment is prepared by the following method:

[0048] (1) Take 1000g of Bupleurum medicinal material, crush it to 20-60 mesh, and extract the volatile oil of Bupleurum with carbon dioxide supercritical extraction equipment:

[0049] Put the pulverized Bupleuri herb into the extraction kettle, and then pump the supercritical medical grade carbon dioxide fluid through the purifier, cooling system and high-pressure pump into the extraction kettle at a flow rate of about 20kg / h. Extraction under the condition of 20MPa pressure for 1.5h;

[0050] The extract is separated in two stages. The operating conditions of the separation kettle I are: pressure 12MPa, temperature 40°C, and the operating conditions of the separation kettle II are: pressure 6MPa, temperature 25°C; collected from the outlet of the two-stage separation kettle Bupleurum supercritical product;

[0051] (2) Distill the Bupleurum supercritical product extracted in step (...

Embodiment 2

[0055] The preparation method of the Bupleurum injection of the present embodiment is as follows:

[0056] (1) Take 1000g of Bupleurum medicinal material, crush it to 20-60 mesh, and extract the volatile oil of Bupleurum with carbon dioxide supercritical extraction equipment: the extraction process is the same as in Example 1, wherein the flow rate of the supercritical medical grade carbon dioxide fluid is 25kg / h, The extraction conditions are: 45°C, 25MPa, and the extraction time is 1h. The operating conditions of the separation tank I are: the pressure is 12MPa, the temperature is 35°C, the operating conditions of the separation tank II are: the pressure is 6MPa, the temperature is 30°C; The supercritical product with Bupleurum volatile oil as the main component is collected at the outlet of the fractional separation kettle;

[0057] (2) Distill the Bupleurum supercritical product extracted in step (1) with 80 times the amount of water for 3 hours to obtain about 2000 mL of ...

Embodiment 3

[0061] The preparation method of the Bupleurum injection of the present embodiment is as follows:

[0062] (1) Take 1000g of Bupleurum medicinal material, crush it to 20-60 mesh, and extract the volatile oil of Bupleurum with carbon dioxide supercritical extraction equipment: the extraction process is the same as in Example 1, wherein the flow rate of the supercritical medical grade carbon dioxide fluid is 25kg / h, The extraction conditions are: 35°C, 20MPa, the extraction time is 2h, the operating conditions of the separation tank I are: pressure 8MPa, temperature 35°C, the operating conditions of the separation tank II are: pressure 7MPa, temperature 30°C; The supercritical product of Bupleurum bupleuri is collected from the outlet of the fractional separation kettle ；

[0063] (2) Distill the Bupleurum supercritical product extracted in step (1) with 60 times the amount of water for 2 hours to obtain about 1500 mL of distillate.

[0064] (3) Add HP-β-CD to the supercritica...

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Abstract

The invention discloses a method for preparing a bupleurum chinense injection. A process for preparing the bupleurum chinense injection comprises the following steps of: extracting a supercritical product taking a bupleurum chinense volatile oil as a main component by using a CO<2> supercritical extraction technique; purifying the supercritical product by a distillation method; and after adding an HP-Beta-CD into the obtained distillate for cladding, adding a corresponding pharmaceutical adjuvant to prepare the bupleurum chinense injection. The process for preparing the bupleurum chinense injection provided by the invention can correctly perform qualitative and quantitative analysis on the volatile oil which is contained in a medicament, and meanwhile, can increase the yield of the bupleurum chinense volatile oil, improve the dissolubility of the bupleurum chinense volatile oil, increase the stability of the medicament, promote medicament absorption and improve bioavailability on the basis of not changing pharmaceutical materials.

Description

technical field [0001] The invention relates to a preparation process of Bupleurum injection. Background technique [0002] Bupleurum is a large number of commonly used traditional Chinese medicines. It is listed as the top grade in "Shen Nong's Materia Medica". , soothes the liver, and is an essential medicine for raising yang. In traditional Chinese medicine, it is mainly used for the treatment of colds and fever, alternating cold and heat, distending pain in the chest and hypochondrium, irregular menstruation, uterine prolapse, prolapse of the anus and other diseases. Modern chemical research has found that the main chemical components of Bupleuri are volatile oil, saikosaponin (saikosapoinsa, b, c, d), polysaccharides and flavonoids, etc., among which the main components of volatile oil are small molecule alkenes, terpenes, and phenols , aldehydes and alcohols, etc., containing eugenol, caproic acid, γ-undecanoic acid lactone and p-methoxybenzodione are the main compone...

Claims

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Application Information

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IPC IPC(8): A61K36/233A61K9/14A61K9/19A61K9/08A61P11/00A61P31/00A61P31/16A61P33/06
Inventor 马家骅索志荣马璇杨兴旺
Owner SICHUAN DE PEI YUAN TRADITIONAL CHINESE MEDICINE SCI & TECH DEV CO LTD
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