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Medicinal hydrophilic polyacrylic ester pressure-sensitive adhesive and preparation method

A technology of polyacrylate and pressure-sensitive adhesives, which is applied in the direction of ester copolymer adhesives, adhesive types, applications, etc., and can solve the problems of poor repeated adhesion, inability to absorb moisture and moisture significantly, and water accumulation in the pasted parts, etc. problems, achieve good water absorption, good moisture vapor transmission rate, and simple preparation process

Inactive Publication Date: 2010-11-03
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This pressure-sensitive adhesive is composed of natural or synthetic rubber and various additives such as thickeners, plasticizers, and stabilizers. Water, causing skin whitening and peeling, and the added low molecular weight components can cause adverse reactions such as skin allergies
[0003] Polyacrylate pressure-sensitive adhesives overcome some of the shortcomings of rubber pressure-sensitive adhesives. In general, no additives are used during use. Compared with traditional rubber pressure-sensitive adhesives, polyacrylate pressure-sensitive adhesives have better moisture absorption and The air permeability has been improved, but it still cannot absorb moisture and water significantly. Therefore, when it is applied to the skin or the affected area for a long time, the skin will still be softened and damaged. In addition, there are problems such as poor repeated adhesion and loss of stickiness when exposed to water.
[0004] Medical and medical pressure-sensitive adhesives often encounter situations that require long-term application. At this time, the water absorption and moisture vapor transmission rate of the pressure-sensitive adhesive are very important. If the water in the skin metabolism cannot evaporate in time, it will cause the stratum corneum Accumulation of bodily fluids leads to a reduction in the strength of the paste, causing the paste material to fall off, or as the paste time prolongs, the degree of hydration and maceration of the outer layer of the stratum corneum increases, resulting in irregular rupture of the deep stratum corneum when the paste material is removed, and damages the skin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] 12.6 g of isooctyl acrylate, 4.26 g of hydroxyethyl acrylate, 7.305 g of methyl acrylate, 0.03 g of glycidyl methacrylate, 0.0660 g of azobisisobutyronitrile and 37.2 g of ethyl acetate Put it into the reactor, stir evenly, and use it as the first mixed solution;

[0071] 8.4 g of isooctyl acrylate, 2.84 g of hydroxyethyl acrylate, 3.896 g of methyl acrylate, 0.02 g of glycidyl methacrylate, 0.044 g of azobisisobutyronitrile and 24.8 g of ethyl acetate Mix well outside the reactor as the second mixture;

[0072] Pass nitrogen into the reactor to drive out oxygen, start heating, and when the temperature of the reaction liquid in the reactor rises to the reflux temperature, start to continuously add the second mixed solution dropwise to keep the reaction temperature in the reactor between 70 and 80°C, 2 hour drops

[0073] After continuing to react for 6 hours, stop heating, lower the temperature to 30° C. under uniform stirring conditions, pour it out, and filter throu...

Embodiment 2

[0076] 17.2 g of isooctyl acrylate, 4.32 g of hydroxyethyl acrylate, 7.12 g of methyl acrylate, 0.056 g of glycidyl methacrylate, 0.104 g of azobisisobutyronitrile and 51.2 g of ethyl acetate Put it into the reactor, stir evenly, and use it as the first mixed solution;

[0077] 4.3 g of isooctyl acrylate, 1.08 g of hydroxyethyl acrylate, 1.78 g of methyl acrylate, 0.014 g of glycidyl methacrylate, 0.026 g of azobisisobutyronitrile and 12.8 g of ethyl acetate Mix well outside the reactor as the second mixture;

[0078] Pass nitrogen into the reactor to drive out oxygen, start heating, and when the temperature of the reaction liquid in the reactor rises to the reflux temperature, start to continuously add the second mixed solution dropwise to keep the reaction temperature in the reactor between 70 and 80°C, 2 Hours run out. After reacting for 6 hours, stop heating, lower the temperature to 35°C under uniform stirring conditions, pour it out, and filter it through a 100-mesh si...

Embodiment 3

[0081] Put 12.6g of isooctyl acrylate, 3.64g of hydroxyethyl acrylate, 6.16g of methyl acrylate, 0.028g of glycidyl methacrylate, 0.049g of azobisisobutyronitrile and 42g of ethyl acetate into In the reactor, stir evenly, as the first mixed solution;

[0082] The isooctyl acrylate of 5.4g, the hydroxyethyl acrylate of 1.56g, the methyl acrylate of 2.64g, the glycidyl methacrylate of 0.012g, the azobisisobutyronitrile of 0.021g and the ethyl acetate of 18g in Mix well outside the reactor as the second mixed solution;

[0083] Pass nitrogen into the reactor to drive out oxygen, start heating, and when the temperature of the reaction liquid in the reactor rises to the reflux temperature, start to continuously add the second mixed solution dropwise to keep the reaction temperature in the reactor between 70 and 80°C, 2 Hours run out. After continuing to react for 5 hours, stop heating, lower the temperature to 40°C under uniform stirring conditions, pour it out, and filter it thr...

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Abstract

The invention discloses medicinal hydrophilic polyacrylic ester pressure-sensitive adhesive, which consists of ethylhexyl acrylate, hydroxyethyl acrylate, methyl acrylate, glycidyl methacrylate, peroxide initiator and acetic ether solvent, wherein the initiator is benzoyl peroxide or azodiisobutyronitrile. A preparation method comprises the following steps of: dividing the components into two parts, and mixing the two parts to form first and second mixed solution respectively; putting the first mixed solution into a reactor, introducing nitrogen into the reactor to remove oxygen, heating the solution to a reflux temperature, starting continuously dripping the second mixed solution into the reactor, reacting the solution at the temperature of between 70 and 80 DEG C, and dripping all the second mixed solution within 1.5 to 2.5 hours; and continuously reacting the solution for 4 to 6 hours after the dripping is finished, stopping heating the solution, cooling the reaction product to between 30 and 40 DEG C, and pouring and sieving the reaction product to obtain the medicinal hydrophilic polyacrylic ester pressure-sensitive adhesive. The preparation method is simple and feasible; and the adhesive has good water absorption property and water vapor penetrability after coating, can be repeatedly adhered for use, has good skin compatibility, can be used as medicinal pressure-sensitive adhesive, and overcomes the defect of hydrophobic pressure-sensitive adhesive.

Description

technical field [0001] The invention belongs to the chemical industry field and relates to a pressure-sensitive adhesive with good water absorption and moisture permeability, which is comfortable to attach and suitable for use as a medical pressure-sensitive adhesive. Background technique [0002] Before the 1950s, medical and medical pressure-sensitive adhesives were mainly rubber. This pressure-sensitive adhesive is composed of natural or synthetic rubber and various additives such as thickeners, plasticizers, and stabilizers. Water can cause skin whitening and peeling, and the added low molecular weight components can cause adverse reactions such as skin allergies. [0003] Polyacrylate pressure-sensitive adhesives overcome some of the shortcomings of rubber pressure-sensitive adhesives. In general, no additives are used during use. Compared with traditional rubber pressure-sensitive adhesives, polyacrylate pressure-sensitive adhesives have better moisture absorption and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09J133/06A61L15/24A61L15/58A61L24/06
Inventor 郝国防任广智
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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