Reinforced anti-adhesion composite gel, preparation method and application

Abstract

The invention relates to the field of biological medicinal materials, and discloses a reinforced anti-adhesion composite gel. The reinforced anti-adhesion composite gel comprises the following components in mass / volume ratio: 0.01 to 8 percent of polysaccharide with anionic groups, 0.0000001 to 1 percent of functional polypeptide with positive charge groups, and 0.05 to 5 percent of polysaccharide with cationic groups or cationic polymerized polypeptide or mixture of the two in any ratio. The invention also provides a preparation method for the reinforced anti-adhesion composite gel. The reinforced anti-adhesion composite gel can effectively reduce the occurrence of adhesion by adding the anti-adhesion functional polypeptide with polyelectrolyte interaction and the polysaccharide with cationic groups and / or cationic polymerized polypeptide into materials.

Description

Technical field [0001] The invention belongs to the field of biomedical materials, and relates to a composite gel with enhanced anti-adhesion function after surgical operation, and a preparation method and application thereof. Background technique [0002] Adhesion between tissues and organs after surgery is a common clinical disease. Adhesion is an abnormal structure formed by the combination of connective tissue fiber bands with adjacent tissues or organs. The formation of adhesions is universal, and it is reported that 50% to 100% of abdominal and pelvic surgery can lead to different degrees of adhesions. Serious clinical complications caused by adhesions include intestinal obstruction, infertility, chronic pelvic pain, etc., which increase the difficulty of reoperation and the potential for further complications. Therefore, in-depth exploration of the causes of adhesion formation and prevention and reduction of postoperative adhesions has become a key research and applicatio...

AI Technical Summary

Problems solved by technology

As a mechanical barrier, it covers tissue or organ wounds in the form of gel or film. It has the characteristics of good absorption and good biocompatibility, but it is absorbed and degraded in about 4 days in the body. However, the completion of adhesion after injury requires For more than 7 days, carboxymethyl cellulose, carboxymethyl chitosan, and hyaluronic acid alone are not effective in preventing adhesions

[0007] In recent years, carboxymethyl cellulose, carboxymethyl chitosan, and hyaluronic acid sugar have been used clinically to prevent adhesions. They are solutions or gels, but they will flow with the body position after being placed in the body. Ensure its concentration and time at the wound site