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RNA interference sequences of glucagon receptor gene

A technology of RNA interference and glucagon, applied in the field of RNA interference sequence, to achieve the effect of reducing blood sugar concentration and improving glucose utilization ability

Inactive Publication Date: 2012-04-18
SHANGHAI JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] After searching the literature of the prior art, it is found that there is no relevant report on the RNA interference sequence of the glucagon receptor gene

Method used

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  • RNA interference sequences of glucagon receptor gene
  • RNA interference sequences of glucagon receptor gene
  • RNA interference sequences of glucagon receptor gene

Examples

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Effect test

Embodiment

[0016] Reagent: Alloxan monohydrate (HPLC pure reagent, purchased from Sigma, USA, product number A7413);

[0017] Glucose determination kit - glucose oxidase-peroxidase method (purchased from Shanghai Rongsheng Biotechnology Co., Ltd., product number 361510, batch number 20030101);

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Abstract

The invention relates to RNA interference sequences of a glucagon receptor gene, which belong to the technical field of genes. The first RNA interference sequence is a double-stranded RNA molecule, the sense strand of the RNA molecule has a sequence shown by SEQ ID NO:1, and the antisense strand of the RNA molecule has a sequence shown by SEQ ID NO:2; the second RNA interference sequence is a double-stranded RNA molecule, the sense strand of the RNA molecule has a sequence shown by SEQ ID NO:3, and the antisense strand of the RNA molecule has a sequence shown by SEQ ID NO:4; and the third RNA interference sequence is a double-stranded RNA molecule, the sense strand of the RNA molecule has a sequence shown by SEQ ID NO:5, and the antisense strand of the RNA molecule has a sequence shown by SEQ ID NO:6. The RNA interference sequences of the invention reduce the blood glucose concentration of mice used as diabetic models effectively and improve the capability of utilizing glucose by the mice.

Description

[0001] The patent application for this invention is China Invention Patent Application No. 200910053750.4, the application date is June 25, 2009, the applicant is "Shanghai Jiaotong University", and the invention name is "RNA interference sequence of glucagon receptor gene". technical field [0002] The invention relates to an RNA interference sequence in the field of gene technology, in particular to an RNA interference sequence of a glucagon receptor (GCGR) gene. Background technique [0003] RNA interference (RNA interference, RNAi) is a phenomenon that inhibits the expression of specific genes in organisms. It means that when there is a double-stranded RNA homologous to the endogenous mRNA coding region in the cell, the mRNA is degraded, resulting in gene expression. The phenomenon of silencing, which occurs at the post-transcriptional level, is also known as post-transcriptional gene silencing. RNA interference is achieved through a relatively stable intermediate medium...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N15/113A61K48/00A61P3/10
Inventor 徐宇虹周洁彭金良
Owner SHANGHAI JIAOTONG UNIV
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