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Medicament coated thrombus filter

A filter and drug technology, which is applied in the direction of drug devices, blood vessel filters, medical science, etc., can solve the problem that the vena cava filter can not fully satisfy the patient, and the patient is inconvenient, so as to reduce the cost of treatment and local thrombus The effect formed

Inactive Publication Date: 2010-09-29
天健医疗科技(苏州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] ②Long-term or even life-long anticoagulant use brings a lot of inconvenience to patients, especially young patients
[0009] Therefore, the vena cava filters on the market so far cannot fully meet the needs of patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A drug-coated thrombus filter, with 316L stainless steel as the filter substrate, is olive-shaped as a whole and distributed in a net shape, and the surface coating of the filter is a layer of vinylidene fluoride-hexafluoropropylene copolymer loaded with streptomycin. The layer thickness was 5 μm and the drug content was 150 μg per square centimeter. In the in vitro test, the drug can be gradually released through the microporous channel formed by the swelling of the polymer within 90 days, and has the effect of thrombolysis and anticoagulation.

Embodiment 2

[0040] A drug-coated thrombus filter, with NiTi alloy as the filter substrate, the surface coating is a streptomycin-loaded vinylidene fluoride-hexafluoropropylene copolymer layer, the coating thickness is 5 μm, and the drug content is per square centimeter 150 μg. In the in vitro test, the drug can be gradually released through the microporous channel formed by the swelling of the polymer within 90 days, and has the effect of thrombolysis and anticoagulation.

Embodiment 3

[0042] A drug-coated thrombus filter, with NiTi alloy as the filter substrate, the surface coating is a streptomycin-loaded vinylidene fluoride-hexafluoropropylene copolymer layer, the coating thickness is 5 μm, and the drug content is per square centimeter 200 μg. In the in vitro test, the drug can be gradually released through the microporous channel formed by the swelling of the polymer within 90 days, and has the effect of thrombolysis and anticoagulation.

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Abstract

The invention discloses a medicament coated thrombus filter. The medicament coated thrombus filter comprises a thrombus filter, a medicament carrier and medicaments, wherein the thrombus filter is positioned on the innermost layer; the medicament carrier is coated on the surface of the thrombus filter; and the medicaments are loaded in the medicament carrier. The provided medicament coated thrombus filter can effectively prevent local thrombus occlusion, inferior vena cava occlusion and complications thereof by taking the thrombus filter as a framework and coating a medicament carrier material containing thrombolytic anticoagulant medicaments on the surface of the thrombus filter to form a medicament coated layer.

Description

technical field [0001] The invention relates to a drug-coated thrombus filter, in particular to an existing thrombus filter as a skeleton, on which a thrombus-dissolving and anticoagulant drug is coated on the surface, which can effectively prevent local thrombus obstruction, inferior vena cava obstruction and its complications. Symptomatic drug coated thrombus filter. Background technique [0002] Pulmonary embolism (referred to as pulmonary embolism, PE) is a series of clinical pathophysiological changes mainly caused by pulmonary circulation dysfunction caused by peripheral deep vein thrombosis or thrombus in the right heart chamber falling off into the pulmonary circulation, blocking the pulmonary artery or its branches. Clinical manifestations are nonspecific, with symptoms such as shortness of breath, chest pain, cough, hemoptysis, or sudden fainting. If the embolism occurs in the main pulmonary artery or the blockage area is too large, resulting in more than 50% bloc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/01A61M31/00A61L31/16
Inventor 唐烈王永刚张弢信朝华潘幸珍
Owner 天健医疗科技(苏州)有限公司
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