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Application of dioscin in preparation of liver-protecting pharmaceutical preparation

The technology of a pharmaceutical preparation and diosgenin is applied to the application field of diosgenin in the preparation of hepatoprotective pharmaceutical preparations, which can solve the problems such as the lack of diosgenin, and achieve the improvement of vitality, inhibition of hepatic steatosis, and inhibition of hepatic lipid peroxidation. Effect

Active Publication Date: 2013-04-17
DALIAN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there is no relevant report on the application of diosgenin in the protection of liver injury and in the preparation of liver protection pharmaceutical preparations.

Method used

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  • Application of dioscin in preparation of liver-protecting pharmaceutical preparation
  • Application of dioscin in preparation of liver-protecting pharmaceutical preparation
  • Application of dioscin in preparation of liver-protecting pharmaceutical preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1: Protective effect of diosgenin on acute liver injury in mice induced by carbon tetrachloride

[0015] 1.1 Diosgenin is used as the main drug, and various dosage forms are made according to the relevant requirements of pharmacy and clinical needs and auxiliary materials.

[0016] 1.1.1 Preparation of Dioscin Tablets

[0017] Take 100 g of diosgenin, 125 g of starch, 175 g of lactose and 100 g of microcrystalline cellulose as raw materials.

[0018] Pass the above-mentioned main ingredients and auxiliary materials through 80 mesh sieves respectively, fully mix uniformly, adopt 5% povidone K30 (PVP K30) ethanol solution as binder, use 20 mesh sieves to granulate, dry at 40-60 ° C, 18 Mesh sieve for granulation, add appropriate amount of lubricant and press into tablets, 0.5g per tablet.

[0019] 1.1.2 Preparation of Dioscin Capsules

[0020] Take diosgenin 100g and starch 300g.

[0021] Pass the above-mentioned main ingredients and auxiliary materials throug...

Embodiment 2

[0044] Example 2: Protective effect of diosgenin on acute liver injury induced by paracetamol

[0045] 2.1 According to the method of Example 1, diosgenin is used as the main drug, and various dosage forms are prepared according to relevant requirements of pharmacy and clinical needs and auxiliary materials.

[0046] 2.2 Establishing the experimental model

[0047] 60 male Kunming mice (20±2g) were randomly divided into 6 groups (blank group, model group, low-dose group, middle-dose group, high-dose group, positive group), 10 in each group. The mice in the blank group and the model group were given CMC-Na solution (0.5%, w / v) by intragastric administration; the oral diosgenin was suspended in the CMC-Na solution (0.5%, w / v), and the low, medium, and The high-dose group was given 25, 50, and 100 mg / kg diosgenin by intragastric administration; the mice in the positive group were given 200 mg / kg silymarin by intragastric administration. Gastrointestinal administration once a da...

Embodiment 3

[0059] Example 3: Protective effect of diosgenin on chronic alcoholic liver in rats

[0060] 3.1 According to the method of Example 1, diosgenin is used as the main drug, and various dosage forms are prepared according to relevant requirements of pharmacy and clinical needs and auxiliary materials.

[0061] 3.2 Establish the experimental model

[0062] 60 SD rats, male, body weight (180±20g), were randomly divided into 6 groups (blank group, model group, low-dose group, middle-low dose, high-dose group and positive group), 10 in each group. Blank group: fed with normal saline, once a day; other groups: given 5% alcohol for 1-3 days, and 10% alcohol for 4-7 days. In the second week, 20% alcohol was administered (2 mL / 100 g body weight, i.g.), once a day. In the third week, 30% alcohol was administered (2 mL / 100 g body weight, i.g.), once a day. From the fourth week to the seventh week, 40% alcohol was fed (2mL / 100g body weight, i.g.), once a day. Suspend diosgenin in CMC-Na...

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Abstract

The invention discloses an application of dioscin in preparation of a liver-protecting pharmaceutical preparation. The pharmaceutical preparation can obviously inhibit increase of activity of aminotransferase and lactate dehydrogenase due to medicines (carbon tetrachloride or paracetamol) and alcohol, and reduce the liver indices, thereby performing the liver-protecting function; the pharmaceutical preparation can enhance the activity of SOD, reduce the content of MDA, increase the content of GSH and inhibit liver lipide overoxidation induced by medicines (carbon tetrachloride or paracetamol); and the pharmaceutical preparation can also reduce the content of TG and TC and inhibit the liver steatosis caused by alcohol. The dioscin can be used as the raw material to prepare various preparation formulations for clinic applications according to pharmaceutic related requirements and clinic requirements, such as tablets, capsules, injections, oral liquids, granules and the like. The invention is safe (no toxicity or side effect), convenient, economical and the like.

Description

Technical field: [0001] The invention relates to a new application of active ingredients of traditional Chinese medicine, especially the application of diosgenin obtained from yam yam in the preparation of hepatoprotective pharmaceutical preparations. Background technique: [0002] The liver is the most important metabolic organ of the human body. Due to long-term damage to the liver by viruses in patients with liver disease, liver function is damaged, resulting in a series of metabolic disorders. Liver cirrhosis and liver cancer are the inevitable results of the development of liver disease. One of the major diseases, it not only causes great suffering to patients, but also brings a heavy burden to families and society. [0003] Dioscin is a natural saponin compound that exists in the rhizomes of Dioscorea nipponica Makino, D.zingiberensis C.H.Wright and D.futschauensis Uline. At present, related reports on diosgenin include: dioscin has cough-relieving, expectorant, desen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P1/16
Inventor 彭金咏孙长凯鲁碧楠郑伶俐刘克辛李镇许丽娜韩旭尹连红许有威齐艳刘月涛
Owner DALIAN MEDICAL UNIVERSITY
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