Human glucose concentration continuous monitoring device based on optical fiber surface plasmon resonance

Abstract

The invention discloses a human glucose concentration continuous monitoring device based on optical fiber surface plasmon resonance. An optical fiber SPR (Surface Plasmon Resonance) probe is implanted in a human body; light emitted by a light source reaches the optical fiber SPR probe via an optical fiber coupler; after SPR attenuation, reflected light reaches a spectrograph through the optical fiber coupler; and a computer analyzes and processes data output by the spectrograph and displays monitoring results. A micro-cavity is fixed outside the optical fiber SPR probe, one side of the micro-cavity is a semitransparent film, and only glucose and other micromolecules can enter the micro-cavity. GGBP proteins or borate polymers are fixed on the goldfilm surface of the optical fiber SPR probe and can carry out specificity absorption to the glucose molecules, thereby improving the measurement sensitivity. The invention can realize human glucose concentration continuous monitoring by measuring the glucose concentration of human body tissue fluid, has high measurement precision and good stability and can realize 24-hour human glucose concentration continuous monitoring and provide comprehensive glucose concentration change data for better guiding the diabetes treatment.

Description

technical field [0001] The invention relates to a device for continuously monitoring the glucose concentration of a human body. In particular, it relates to a continuous monitoring device for human glucose concentration based on optical fiber surface plasmon resonance, which includes a light source, an optical fiber coupler, an optical fiber SPR probe, a spectrometer and a computer. Background technique [0002] With the improvement of people's living standards, changes in diet structure and lifestyle, population aging and the increase in the incidence of obesity, the incidence of diabetes is increasing year by year. The importance of continuous blood glucose monitoring in the diagnosis and treatment of diabetes has been increasingly recognized by people. If painless and uninterrupted continuous blood sugar monitoring can be performed on patients and more closely data on blood sugar drift changes can be provided, it will be able to reflect the "full picture" of the patient'...

AI Technical Summary

Problems solved by technology

However, at this stage, some optical fiber SPR measurement devices have low precision and cannot meet the requirements for measuring the glucose concentration in interstitial fluid; some have poor stability and cannot continuously measure for a long time; some cannot be implanted into the human body due to biocompatibility and other issues. Measurement

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