Design of high-density microelectrode array outer-layer artificial retina front-end system

Abstract

The invention relates to a method for designing a high-density outer-layer artificial retina system, belonging to the field of the biological engineering. The method comprises the following steps: a charge-coupled device (CCD) image sensor is used for acquiring extraocular video images; the extraocular video images are pre-processed; the region of interest (ROI) in the extraocular video images is extracted by using a saliency map and a visual attention saliency map; the high-precision extraocular video images are effectively mapped and then the low-precision extraocular video images are effectively mapped; after the ROI in the extraocular video images is encoded and modulated, the data is wirelessly transmitted by using one pair of coupling coils and the energy is wirelessly transmitted by using another pair of coupling coils so as to effectively solve the conflict between the high-transmission data volume and the high-transmission energy efficiency of a wireless transmission unit; on the receiving end, after the modulated data is demodulated and decoded, a micro-stimulator adopts the driving unit multiplexing method to effectively reduce the area and adopts the wide-swing cascode circuit design and the charge balance mechanism to improve the biological adaptation and the security; and the RF energy is subjected to the current rectifying and the voltage stabilizing to supply energy to all implanted equipment.

Description

technical field [0001] The invention relates to a design method of a high-density microelectrode array outer-layer artificial retina front-end system in the technical field of biomedical engineering, in particular to a high-density micro-electrode array outer-layer artificial retina system that provides visual information stimulation current Design methodology for pulsed front-end system devices. technical background [0002] The application of artificial retina technology is for blind people who have lost vision due to retinal diseases such as Retinitis Pigmentosa (RP) or Age-related Macular Degeneration (AMD). Depending on the implantation position of the microelectrode array in the retina, its system solutions can be divided into two types: Sub-retinal type (placed in the retina) and Epi-retinal type (placed on the retinal surface). Regardless of the system scheme, the artificial retina system is divided into two parts: the intraocular system and the extraocular system. ...

AI Technical Summary

Problems solved by technology

Compared with low-density microelectrode array artificial retina system, the design of high-density microelectrode array artificial retina system mainly needs to pay attention to the following key issues: (1) Under the limited microelectrode array, use image processing technology to increase the image resolution as much as possible. Effective information, so as to provide better image perception information for the visually impaired; (2) As the number of electrodes increases, the amount of data that needs to be transmitted from the outside of the eye to the inside of the eye also increases. When a link is used for data and energy When transmitting, it is difficult to ensure a large data bandwidth and high energy transmission efficiency at the same time; (3) the circuit area of ​​the stimulator of the high-density microelectrode array; (4) the biological factors of the intraocular implant device Issues such as biocompatibility, biosafety, etc.

There is currently no specific technical solution to the above problems

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