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Preparation method of oxazole spice for tobacco

A technology for tobacco flavors and oxazoles, which is applied in the field of preparation of azole flavors for tobacco, can solve the problems of complex extraction of final products, low yield, strong reaction and dissolution toxicity, difficult reaction control, etc. Aroma, anti-irritant effect

Inactive Publication Date: 2010-07-21
CHINA TOBACCO HUNAN INDAL CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above method has disadvantages such as complex operation and difficult control, or complex extraction of the final product, low yield, or strong toxicity of reaction dissolution and difficult removal.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Accurately measure 53.4g of analytically pure grade alanine and 47.56g of analytically pure redistilled 2,3-butanedione, add them to a beaker containing 200mL of freshly distilled diglyme, and stir with a magnetic stirrer for 45- Mix well for 50 minutes; then add the resulting mixed solution into the autoclave, close the lid of the autoclave, and open the nitrogen inflation valve and air exhaust valve at the same time until the air is completely discharged from the exhaust valve, then close the exhaust valve, and then The pressure in the reactor was adjusted to 1.5 atmospheres using nitrogen pressure. Turn on the stirring paddle and the temperature control pump, the stirring speed is 200 rpm, the temperature is controlled at 160° C., and the reaction is terminated in 6 hours. The temperature of the reactor was lowered to room temperature by a cooling pump. Add NaCl powder to the cooled reaction liquid until a saturated solution is formed, then extract the extract with ...

Embodiment 2

[0026] Proceed in the same manner as in Example 1, but weigh 72.64 g of analytically pure cysteine, 47.56 g of redistilled 2,3 diacetyl of analytically pure grade and 200 mL of freshly distilled diglyme and add them to a 500 mL beaker Mixed by a magnetic stirrer, put into the reaction kettle, under the condition of no air, the temperature is 160°C, the pressure is 1.5 atmospheres, the stirring speed is 200 rpm, and the reaction is for 7 hours. After extracting and rectifying, the total amount of the final fraction is 40mL. for the product.

Embodiment 3

[0028] Proceed in the same manner as in Example 1, but weigh 26.7 g of analytically pure alanine, 36.32 g of analytically pure cysteine, 47.56 g of redistilled 2,3-butanedione of analytically pure grade and 200 mL of freshly distilled diethylene glycol Add dimethyl ether into a 500mL beaker, mix it with a magnetic stirrer, put it into a reaction kettle, and in the absence of air, the temperature is 160°C, the pressure is 1.5 atmospheres, the stirring speed is 200 rpm, and the reaction is carried out for 6 hours. After extraction and rectification, The total amount of final distillates obtained is 40mL which is the product.

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PUM

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Abstract

The invention relates to a preparation method of oxazole spice for tobacco; in the method, one of lactamic acid or aminothiopropionic acid or the mixture of the lactamic acid and the aminothiopropionic acid with arbitrary proportion and 2,3-butanedione are used as raw materials, diglyme is used as solvent, the raw materials are reacted for 6-8 hours at 155-175 DEG C under the condition of 1.5-2.0 of barometric pressure, and then the organic solvent extraction and rectification are carried out to obtain the product; the invention provides a brand new preparation method in the preparation field of the oxazole spice for tobacco; and the method has simple operation, is easy to control the reaction and has high purity and yield of final products.

Description

technical field [0001] The invention belongs to the technical field of spice preparation for improving the aroma quality of tobacco. More specifically, the present invention relates to a preparation method of azole tobacco flavoring. Background technique [0002] Oxazole compounds are an important class of heterocyclic compounds, and some compounds with oxazole rings have biological activity. For example, 2-aminooxazole has fungicidal, antibacterial and antiviral effects. At the same time, they also have a wide range of applications in intermediates and drug synthesis. And some oxazole compounds have a strong nutty and toasted aroma, such as: 2,4,5-trimethyloxazole and 2,4,5-trimethyl-3-oxazoline. [0003] 2,4,5-Trimethyl-3-oxazoline was detected from cooked beef volatiles in 1968, and it was the first oxazole to be discovered. Oxazoles were subsequently found in cocoa, coffee, and baked potatoes. The presence of oxazoles increases the aroma of food. With the continuous...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D263/18A24B15/36
Inventor 杨华武刘艺赵震毅谭新良钟科军卢红兵刘金云
Owner CHINA TOBACCO HUNAN INDAL CORP
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