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Calcium folinate and phenyl alanine composition and preparation method thereof

A technology of phenylalanine and calcium folinate, applied in the field of medicine, can solve the problems of poor water solubility, toxic effect, and poor stability of calcium folinate, and achieve the effects of excellent appearance, reduction of toxic and side effects, and improvement of water solubility

Active Publication Date: 2012-01-25
BEIJING SIHUAN PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] In order to overcome the problems of poor water solubility, poor stability and toxic effects of calcium folinate, and make patients use it more safely and at a lower cost, the inventors of the present invention provide a composition of calcium folinate and phenylalanine and a preparation method thereof

Method used

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  • Calcium folinate and phenyl alanine composition and preparation method thereof
  • Calcium folinate and phenyl alanine composition and preparation method thereof
  • Calcium folinate and phenyl alanine composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0132] Example The preparation of the freeze-dried powder preparation of the composition calcium folinate and phenylalanine of the present invention

[0133] 1. Prescription

[0134] Prescription 1:

[0135] Calcium folinate 100g

[0136] Phenylalanine 5g

[0137] Dextran 40 55g

[0138] Add water for injection to 1200mL

[0139] A total of 1000 bottles were made

[0140] Prescription 2:

[0141] Calcium folinate 100g

[0142] Phenylalanine 10g

[0143] Dextran 40 50g

[0144] Add water for injection to 1200mL

[0145] A total of 1000 bottles were made

[0146] Prescription 3:

[0147] Calcium folinate 100g

[0148] Phenylalanine 15g

[0149] Dextran 40 45g

[0150] Add water for injection to 1200mL

[0151] A total of 1000 bottles were made

[0152] Prescription 4:

[0153] ...

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Abstract

The invention belongs to the technical field of medicine, in particular to a calcium folinate and phenyl alanine composition and a preparation method thereof, wherein in the composition, the weight ratio of the calcium folinate to the phenyl alanine is 1 / 0.01 to 0.8. The invention also provides the preparation method of a freeze-dried powder preparation of the composition and the application of the composition to the preparation of anemia treating and detoxification medicine.

Description

1. Technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a composition of calcium folinate and phenylalanine, a preparation method thereof, and an application in preparation of medicines for treating anemia and detoxification. 2. Background technology [0002] Folic acid is an indispensable component in the process of nucleic acid protein synthesis and erythropoiesis. For some patients with giant red blood cell anemia, it can stimulate the production of red blood cells and platelets. However, folic acid must first be converted into effective forms of formazan in the liver and bone marrow. Acyltetrahydrofolate, then participates in the synthesis of nucleic acids as a coenzyme. Calcium Folinate (Calcium Folinate, CF) is a formylated derivative of the reduced form of folic acid. It is the activated form of folic acid in the body. [0003] The following figure is the structural formula of calcium folinate: [0004] [...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/519A61K9/19A61P39/02A61P7/06A61K47/16
Inventor 车冯升郭维城贾中新霍彩霞孟宪慧
Owner BEIJING SIHUAN PHARMA
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